EC Number | Cloned (Comment) | Organism |
---|---|---|
1.5.1.6 | cloning of the cDNA encoding FDH | Rattus norvegicus |
1.5.1.6 | cloning of the cDNA encoding FDH, cells from several tumor cell lines are transfected with FDH cDNA cloned into pcDNA 3.1+ vector using LipofectAMINE, expression of FDH inhibits the proliferation of the cell lines as a result of its enzymatic activity | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.5.1.6 | C707A | - |
Rattus norvegicus |
1.5.1.6 | C707A | catalytically inactive mutant | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | Rattus norvegicus | - |
tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | Homo sapiens | regulation of the ratio of 10-formyltetrahydrofolate to tetrahydrofolate and of the purine biosynthesis through control of the level of 10-formyltetrahydrofolate, down-regulation of FDH in tumors is one of the cellular mechanisms that enhance proliferation, FDH possesses tumor specific suppressor effects | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.6 | Homo sapiens | - |
- |
- |
1.5.1.6 | Rattus norvegicus | - |
male rats | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.5.1.6 | A-549 cell | significantly decreased levels of FDH and its mRNA in 15 tested tumors compared with normal tissues, strong down-regulation of FDH on both the mRNA and protein level in tumors | Homo sapiens | - |
1.5.1.6 | brain | moderate FDH mRNA level | Homo sapiens | - |
1.5.1.6 | DU-145 cell | - |
Homo sapiens | - |
1.5.1.6 | heart | - |
Rattus norvegicus | - |
1.5.1.6 | heart | moderate FDH mRNA level | Homo sapiens | - |
1.5.1.6 | HEK-293 cell | transformed embryonic kidney cell line HEK-293A | Homo sapiens | - |
1.5.1.6 | Hep-G2 cell | - |
Homo sapiens | - |
1.5.1.6 | kidney | - |
Rattus norvegicus | - |
1.5.1.6 | kidney | high FDH mRNA level, specialized organ of folate metabolism | Homo sapiens | - |
1.5.1.6 | liver | specialized organ of folate metabolism | Homo sapiens | - |
1.5.1.6 | liver | high FDH mRNA level | Homo sapiens | - |
1.5.1.6 | liver | high FDH mRNA level | Rattus norvegicus | - |
1.5.1.6 | lung | moderate FDH mRNA level | Homo sapiens | - |
1.5.1.6 | additional information | FDH expression is highly tissue specific, very low or nondetectable levels of FDH mRNA in placenta, spleen, colon, small intestine, and leukocytes | Homo sapiens | - |
1.5.1.6 | muscle | moderate FDH mRNA level in skeletal muscle | Homo sapiens | - |
1.5.1.6 | ovary | moderate FDH mRNA level | Homo sapiens | - |
1.5.1.6 | pancreas | high FDH mRNA level | Homo sapiens | - |
1.5.1.6 | PC-3 cell | - |
Homo sapiens | - |
1.5.1.6 | PPC-1 cell | - |
Homo sapiens | - |
1.5.1.6 | prostate gland | moderate FDH mRNA level | Homo sapiens | - |
1.5.1.6 | testis | moderate FDH mRNA level | Homo sapiens | - |
1.5.1.6 | thymus | moderate FDH mRNA level | Homo sapiens | - |
1.5.1.6 | Tsu-Pr1 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | - |
Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | - |
Rattus norvegicus | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | regulation of the ratio of 10-formyltetrahydrofolate to tetrahydrofolate and of the purine biosynthesis through control of the level of 10-formyltetrahydrofolate, down-regulation of FDH in tumors is one of the cellular mechanisms that enhance proliferation, FDH possesses tumor specific suppressor effects | Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Homo sapiens | |
1.5.1.6 | 10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Rattus norvegicus | |
1.5.1.6 | NADP+ | - |
Homo sapiens | |
1.5.1.6 | NADP+ | - |
Rattus norvegicus | |
1.5.1.6 | tetrahydrofolate | - |
Homo sapiens | |
1.5.1.6 | tetrahydrofolate | - |
Rattus norvegicus |