EC Number | Application | Comment | Organism |
---|---|---|---|
1.5.1.6 | medicine | formic acidemia: toxicity of methanol in humans is correlated with formate accumulation as a result of low rates of formate oxidation, which is in vivo dependent on enzyme activity and on hepatic tetrahydrofolate levels | Homo sapiens |
EC Number | General Stability | Organism |
---|---|---|
1.5.1.6 | in general activity is labile | Homo sapiens |
1.5.1.6 | in general activity is labile | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.6 | 0.02 | - |
10-formyltetrahydrofolate | - |
Rattus norvegicus | |
1.5.1.6 | 0.05 | - |
10-formyltetrahydrofolate | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.5.1.6 | cytosol | - |
Homo sapiens | 5829 | - |
1.5.1.6 | cytosol | - |
Rattus norvegicus | 5829 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.5.1.6 | 96000 | - |
x * 96000, SDS-PAGE | Homo sapiens |
1.5.1.6 | 96000 | - |
x * 96000, SDS-PAGE | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | Rattus norvegicus | - |
tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | Homo sapiens | folate-dependent pathway is the exclusive route of formate metabolism in primates, plays major role in disposition of formate generated from one-carbon moieties of environmental chemicals, drugs, and foods, importance in the toxicity of methanol | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.6 | Homo sapiens | - |
- |
- |
1.5.1.6 | Rattus norvegicus | - |
Sprague-Dawley rats | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.5.1.6 | free of 10-formyltetrahydrofolate hydrolase activity | Homo sapiens |
1.5.1.6 | free of 10-formyltetrahydrofolate hydrolase activity | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.5.1.6 | liver | activity in human liver is 26% of that in rat liver, reduced amount of enzyme in human liver | Homo sapiens | - |
1.5.1.6 | liver | activity in human liver is 26% of that in rat liver, reduced amount of enzyme in human liver | Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.5.1.6 | additional information | - |
- |
Homo sapiens |
1.5.1.6 | additional information | - |
- |
Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | - |
Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | - |
Rattus norvegicus | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | folate-dependent pathway is the exclusive route of formate metabolism in primates, plays major role in disposition of formate generated from one-carbon moieties of environmental chemicals, drugs, and foods, importance in the toxicity of methanol | Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.5.1.6 | ? | x * 96000, SDS-PAGE | Homo sapiens |
1.5.1.6 | ? | x * 96000, SDS-PAGE | Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.5.1.6 | additional information | - |
assay at room temperature | Homo sapiens |
1.5.1.6 | additional information | - |
assay at room temperature | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Homo sapiens | |
1.5.1.6 | 10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Rattus norvegicus | |
1.5.1.6 | NADP+ | - |
Homo sapiens | |
1.5.1.6 | NADP+ | - |
Rattus norvegicus | |
1.5.1.6 | tetrahydrofolate | - |
Homo sapiens | |
1.5.1.6 | tetrahydrofolate | - |
Rattus norvegicus |