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Literature summary extracted from

  • Gardam, M.A.; Mejia, N.R.; MacKenzie, R.E.
    The NADP-dependent trifunctional methylenetetrahydrofolate dehydrogenase purified from mouse liver is immunologically distinct from the mouse NAD-dependent [corrected] bifunctional enzyme [published erratum appears in Biochem Cell Biol 1988 May;66(5):459] (1988), Biochem. Cell Biol., 66, 66-70.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.5 0.008
-
 NADP+
-
 Mus musculus
1.5.1.5 0.015
-
 5,10-methylenetetrahydrofolate
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.5 5,10-methylenetetrahydrofolate + NADP+ Mus musculus
-
 5,10-methenyltetrahydrofolate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.5 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.5 trifunctional enzyme: methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrase, formyltetrahydrofolate synthetase Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.5 liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.5 6.53
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.5 5,10-methylenetetrahydrofolate + NADP+
-
 Mus musculus 5,10-methenyltetrahydrofolate + NADPH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.5 NADP+
-
 Mus musculus