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Literature summary extracted from

  • Matthews, R.G.; Daubner, S.C.
    Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues (1982), Adv. Enzyme Regul., 20, 123-131.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.20 dihydrofolate competitive with respect to 5,10-methylenetetrahydrofolate and uncompetitive with respect to NADPH Sus scrofa
1.5.1.20 dihydropteroylpolyglutamate
-
 Sus scrofa
1.5.1.20 Polyglutamate analogues
-
 Sus scrofa
1.5.1.20 S-adenosylmethionine inhibition partially reversed by S-adenosylhomocysteine Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.20 5,10-methylenetetrahydrofolate + NADPH Sus scrofa branch point in folate metabolism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.20 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.20 homogeneity Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.20 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.20 5,10-methylenetetrahydrofolate + NADPH
-
 Sus scrofa 5-methyltetrahydrofolate + NADP+
-
 ir
1.5.1.20 5,10-methylenetetrahydrofolate + NADPH branch point in folate metabolism Sus scrofa ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.20 FAD flavoprotein Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.20 additional information
-
 additional information dihydropteroylpolyglutamate inhibitors with different numbers of glutamyl residues Sus scrofa
1.5.1.20 0.0065
-
 dihydrofolate
-
 Sus scrofa