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Literature summary extracted from
- DELTA1-pyrroline-5-carboxylate dehydrogenase (ox liver) (oxidation of DELTA1-pyrroline-5-carboxylate to glutamate) (1971), Methods Enzymol., 17B, 262-265.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.88 | 4-aminobutyrate | - |
Bos taurus |  |
| 1.2.1.88 | 5-Aminopentanoate | - |
Bos taurus | |
| 1.2.1.88 | 6-aminohexanoate | - |
Bos taurus | |
| 1.2.1.88 | ADP | - |
Bos taurus | |
| 1.2.1.88 | AMP | - |
Bos taurus | |
| 1.2.1.88 | arsenite | - |
Bos taurus | |
| 1.2.1.88 | ATP | - |
Bos taurus | |
| 1.2.1.88 | L-hydroxyproline | - |
Bos taurus | |
| 1.2.1.88 | p-hydroxymercuribenzoate | - |
Bos taurus | |
| 1.2.1.88 | piperidin-2-one | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.88 | 0.053 | - |
NAD+ | - |
Bos taurus | |
| 1.2.1.88 | 0.062 | - |
1-pyrroline-5-carboxylate | with NADP+ | Bos taurus | |
| 1.2.1.88 | 0.12 | - |
NADP+ | - |
Bos taurus | |
| 1.2.1.88 | 0.29 | - |
1-pyrroline-5-carboxylate | with NAD+ | Bos taurus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.1.88 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.2.1.88 | - |
Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.2.1.88 | liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.88 | 0.55 | - |
- |
Bos taurus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.2.1.88 | -15°C, 50% loss of activity, 2 months | Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.88 | 1-pyrroline-5-carboxylate + NAD+ + H2O | - |
Bos taurus | L-glutamate + NADH | - |
ir | |
| 1.2.1.88 | 1-pyrroline-5-carboxylate + NADP+ + H2O | - |
Bos taurus | L-glutamate + NADPH + H+ | - |
r | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.88 | 8.5 | 8.6 | - |
Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.88 | NAD+ | preferentially | Bos taurus | |
| 1.2.1.88 | NADP+ | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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