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Literature summary extracted from

  • Meister, A.; Radhakrishnan, A.N.; Buckley, S.D.
    Enzymatic synthesis of L-pipecolic acid and L-proline (1957), J. Biol. Chem., 229, 789-800.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.1 0.038
-
 NADPH + DELTA1-pyrroline-2-carboxylate Rattus norvegicus
1.5.1.1 0.043
-
 NADH + DELTA1-pyrroline-2-carboxylate Rattus norvegicus
1.5.1.1 0.06
-
 DELTA1-piperidine-2-carboxylate cosubstrate NADH Rattus norvegicus
1.5.1.1 0.074
-
 NADH + DELTA1-piperidine-2-carboxylate Rattus norvegicus
1.5.1.1 0.082
-
 DELTA1-pyrroline-2-carboxylate cosubstrate NADH Rattus norvegicus
1.5.1.1 0.12
-
 DELTA1-pyrroline-2-carboxylate cosubstrate NADPH Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.1 DELTA1-piperidine-2-carboxylate + NAD(P)H Vigna radiata var. radiata
-
 L-pipecolic acid + NAD(P)+
-
 ir
1.5.1.1 DELTA1-piperidine-2-carboxylate + NAD(P)H Rattus norvegicus
-
 L-pipecolic acid + NAD(P)+
-
 ir
1.5.1.1 DELTA1-piperidine-2-carboxylate + NAD(P)H Neurospora crassa
-
 L-pipecolic acid + NAD(P)+
-
 ir
1.5.1.1 DELTA1-piperidine-2-carboxylate + NAD(P)H Pisum sativum
-
 L-pipecolic acid + NAD(P)+
-
 ir
1.5.1.1 DELTA1-piperidine-2-carboxylate + NAD(P)H Klebsiella aerogenes
-
 L-pipecolic acid + NAD(P)+
-
 ?
1.5.1.1 DELTA1-pyrroline-2-carboxylate + NAD(P)H Vigna radiata var. radiata
-
 L-proline + NAD(P)+
-
 ir
1.5.1.1 DELTA1-pyrroline-2-carboxylate + NAD(P)H Rattus norvegicus
-
 L-proline + NAD(P)+
-
 ir
1.5.1.1 DELTA1-pyrroline-2-carboxylate + NAD(P)H Neurospora crassa
-
 L-proline + NAD(P)+
-
 ir
1.5.1.1 DELTA1-pyrroline-2-carboxylate + NAD(P)H Pisum sativum
-
 L-proline + NAD(P)+
-
 ir
1.5.1.1 DELTA1-pyrroline-2-carboxylate + NAD(P)H Klebsiella aerogenes
-
 L-proline + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.1 Klebsiella aerogenes
-
-
-
1.5.1.1 Neurospora crassa
-
-
-
1.5.1.1 Pisum sativum
-
-
-
1.5.1.1 Rattus norvegicus
-
-
-
1.5.1.1 Vigna radiata var. radiata
-
-
-
1.5.1.2 Pisum sativum
-
-
-
1.5.1.2 Rattus norvegicus
-
-
-
1.5.1.2 Vigna radiata var. radiata
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.1
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.1 brain
-
 Rattus norvegicus
-
1.5.1.1 heart
-
 Rattus norvegicus
-
1.5.1.1 kidney
-
 Rattus norvegicus
-
1.5.1.1 liver
-
 Rattus norvegicus
-
1.5.1.1 seed germinated seed Vigna radiata var. radiata
-
1.5.1.1 seed germinated seed Pisum sativum
-
1.5.1.1 skeletal muscle
-
 Rattus norvegicus
-
1.5.1.1 spleen
-
 Rattus norvegicus
-
1.5.1.1 testis
-
 Rattus norvegicus
-
1.5.1.2 kidney
-
 Rattus norvegicus
-
1.5.1.2 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.1 additional information
-
 specific activities in homogenates of various organs Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.1 1-pyrroline-2-carboxylate + NADH + H+
-
 Rattus norvegicus L-proline + NAD+
-
 r
1.5.1.1 DELTA1-piperidine-2-carboxylate + NAD(P)H
-
 Vigna radiata var. radiata L-pipecolic acid + NAD(P)+
-
 ir
1.5.1.1 DELTA1-piperidine-2-carboxylate + NAD(P)H
-
 Rattus norvegicus L-pipecolic acid + NAD(P)+
-
 ir
1.5.1.1 DELTA1-piperidine-2-carboxylate + NAD(P)H
-
 Neurospora crassa L-pipecolic acid + NAD(P)+
-
 ir
1.5.1.1 DELTA1-piperidine-2-carboxylate + NAD(P)H
-
 Pisum sativum L-pipecolic acid + NAD(P)+
-
 ir
1.5.1.1 DELTA1-piperidine-2-carboxylate + NAD(P)H
-
 Klebsiella aerogenes L-pipecolic acid + NAD(P)+
-
 ?
1.5.1.1 DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
 Vigna radiata var. radiata L-proline + NAD(P)+
-
 ir
1.5.1.1 DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
 Rattus norvegicus L-proline + NAD(P)+
-
 ir
1.5.1.1 DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
 Neurospora crassa L-proline + NAD(P)+
-
 ir
1.5.1.1 DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
 Pisum sativum L-proline + NAD(P)+
-
 ir
1.5.1.1 DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
 Klebsiella aerogenes L-proline + NAD(P)+
-
 ?
1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+
-
 Vigna radiata var. radiata L-proline + NAD(P)+
-
 ?
1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+
-
 Rattus norvegicus L-proline + NAD(P)+
-
 ?
1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+
-
 Pisum sativum L-proline + NAD(P)+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.1 6
-
 DELTA1-piperidine-2-carboxylate Rattus norvegicus
1.5.1.1 6.8
-
 DELTA1-pyrroline-2-carboxylate Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.1 NADH
-
 Vigna radiata var. radiata
1.5.1.1 NADH
-
 Rattus norvegicus
1.5.1.1 NADH
-
 Neurospora crassa
1.5.1.1 NADH
-
 Pisum sativum
1.5.1.1 NADH
-
 Klebsiella aerogenes
1.5.1.1 NADPH
-
 Vigna radiata var. radiata
1.5.1.1 NADPH
-
 Rattus norvegicus
1.5.1.1 NADPH
-
 Neurospora crassa
1.5.1.1 NADPH
-
 Pisum sativum
1.5.1.1 NADPH
-
 Klebsiella aerogenes