BRENDA - Enzyme Database

L-Pipecolate formation in the mammalian brain. Regional distribution of DELTA1-pyrroline-2-carboxylate reductase activity

Garweg, G.; von Rehren, D.; Hintze, U.; J. Neurochem. 35, 616-621 (1980)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.5.1.1
additional information
not: p-hydroxymercuribenzoate
Mus musculus
1.5.1.1
N-formyl-L-methionine
non competitive inhibition, EDTA decreases the inhibition rate
Mus musculus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.5.1.1
0.02
-
NADH
+ DELTA1-piperidine-2-carboxylate
Mus musculus
1.5.1.1
0.21
-
DELTA1-piperidine-2-carboxylate
-
Mus musculus
1.5.1.1
0.43
-
NADH
+ DELTA1-pyrroline-2-carboxylate
Mus musculus
1.5.1.1
0.86
-
DELTA1-pyrroline-2-carboxylate
-
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
Mus musculus
-
L-pipecolic acid + NAD(P)+
-
-
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
Canis lupus familiaris
-
L-pipecolic acid + NAD(P)+
-
-
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
Cercocebus sp.
-
L-pipecolic acid + NAD(P)+
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Mus musculus
-
L-proline + NAD(P)+
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Canis lupus familiaris
-
L-proline + NAD(P)+
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Cercocebus sp.
-
L-proline + NAD(P)+
-
-
?
Organism
EC Number
Organism
UniProt
Commentary
Textmining
1.5.1.1
Canis lupus familiaris
-
beagle
-
1.5.1.1
Cercocebus sp.
-
monkey
-
1.5.1.1
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.5.1.1
brain
prosencephalic region
Canis lupus familiaris
-
1.5.1.1
brain
prosencephalic region
Cercocebus sp.
-
1.5.1.1
brain
prosencephalic region
Mus musculus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.5.1.1
additional information
-
specific activities in various brain regions
Canis lupus familiaris
1.5.1.1
additional information
-
specific activities in various brain regions
Cercocebus sp.
1.5.1.1
additional information
-
specific activities in various brain regions
Mus musculus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-pipecolic acid + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-pipecolic acid + NAD(P)+
-
392037
Mus musculus
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-pipecolic acid + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-pipecolic acid + NAD(P)+
-
392037
Canis lupus familiaris
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-pipecolic acid + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-pipecolic acid + NAD(P)+
-
392037
Cercocebus sp.
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-proline + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-proline + NAD(P)+
-
392037
Mus musculus
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-proline + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-proline + NAD(P)+
-
392037
Canis lupus familiaris
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-proline + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-proline + NAD(P)+
-
392037
Cercocebus sp.
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.5.1.1
30
-
assay at
Canis lupus familiaris
1.5.1.1
30
-
assay at
Cercocebus sp.
1.5.1.1
30
-
assay at
Mus musculus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.5.1.1
5.2
-
DELTA1-pyrroline-2-carboxylate
Mus musculus
1.5.1.1
5.4
-
DELTA1-piperidine-2-carboxylate
Mus musculus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.5.1.1
NADH
-
Canis lupus familiaris
1.5.1.1
NADH
-
Cercocebus sp.
1.5.1.1
NADH
-
Mus musculus
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.5.1.1
0.18
-
N-formyl-L-methionine
-
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.5.1.1
NADH
-
Canis lupus familiaris
1.5.1.1
NADH
-
Cercocebus sp.
1.5.1.1
NADH
-
Mus musculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.5.1.1
additional information
not: p-hydroxymercuribenzoate
Mus musculus
1.5.1.1
N-formyl-L-methionine
non competitive inhibition, EDTA decreases the inhibition rate
Mus musculus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.5.1.1
0.18
-
N-formyl-L-methionine
-
Mus musculus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.5.1.1
0.02
-
NADH
+ DELTA1-piperidine-2-carboxylate
Mus musculus
1.5.1.1
0.21
-
DELTA1-piperidine-2-carboxylate
-
Mus musculus
1.5.1.1
0.43
-
NADH
+ DELTA1-pyrroline-2-carboxylate
Mus musculus
1.5.1.1
0.86
-
DELTA1-pyrroline-2-carboxylate
-
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
Mus musculus
-
L-pipecolic acid + NAD(P)+
-
-
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
Canis lupus familiaris
-
L-pipecolic acid + NAD(P)+
-
-
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
Cercocebus sp.
-
L-pipecolic acid + NAD(P)+
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Mus musculus
-
L-proline + NAD(P)+
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Canis lupus familiaris
-
L-proline + NAD(P)+
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
Cercocebus sp.
-
L-proline + NAD(P)+
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.5.1.1
brain
prosencephalic region
Canis lupus familiaris
-
1.5.1.1
brain
prosencephalic region
Cercocebus sp.
-
1.5.1.1
brain
prosencephalic region
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.5.1.1
additional information
-
specific activities in various brain regions
Canis lupus familiaris
1.5.1.1
additional information
-
specific activities in various brain regions
Cercocebus sp.
1.5.1.1
additional information
-
specific activities in various brain regions
Mus musculus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-pipecolic acid + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-pipecolic acid + NAD(P)+
-
392037
Mus musculus
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-pipecolic acid + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-pipecolic acid + NAD(P)+
-
392037
Canis lupus familiaris
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-pipecolic acid + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-pipecolic acid + NAD(P)+
-
392037
Cercocebus sp.
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-proline + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Mus musculus
L-proline + NAD(P)+
-
392037
Mus musculus
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-proline + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Canis lupus familiaris
L-proline + NAD(P)+
-
392037
Canis lupus familiaris
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-proline + NAD(P)+
-
-
-
?
1.5.1.1
DELTA1-pyrroline-2-carboxylate + NAD(P)H
-
392037
Cercocebus sp.
L-proline + NAD(P)+
-
392037
Cercocebus sp.
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.5.1.1
30
-
assay at
Canis lupus familiaris
1.5.1.1
30
-
assay at
Cercocebus sp.
1.5.1.1
30
-
assay at
Mus musculus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.5.1.1
5.2
-
DELTA1-pyrroline-2-carboxylate
Mus musculus
1.5.1.1
5.4
-
DELTA1-piperidine-2-carboxylate
Mus musculus