Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Castric, P.
    Influence of oxygen on the Pseudomonas aeruginosa hydrogen cyanide synthase (1994), Curr. Microbiol., 29, 19-21.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.99.5 pyocyanin secondary metabolite, supports HCS mediated cyanide production Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.99.5 O2
-
 Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.99.5 glycine + O2 Pseudomonas aeruginosa
-
 HCN + CO2 + 2 H2O
-
 ?
1.4.99.5 glycine + O2 Chromobacterium violaceum
-
 HCN + CO2 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.99.5 Chromobacterium violaceum
-
-
-
1.4.99.5 Pseudomonas aeruginosa
-
-
-
1.4.99.5 Pseudomonas aeruginosa 9-D2
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
1.4.99.5 synthesis of HCN is repressed under highly aerobic conditions, cyanogenic enzyme system is rapidly inactivated, both in vivo and in vitro, in the presence of oxygen Pseudomonas aeruginosa

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.99.5 partially Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.99.5 glycine + 2,2'-di-(p-nitrophenyl-5,5')-(diphenyl)-3,3'-(3,3'-dimethoxy-4,4'-diphenylene) ditetrazolium chloride NBT Pseudomonas aeruginosa HCN + ?
-
 ?
1.4.99.5 glycine + 2,6-dichlorophenol-indophenol DCIP Pseudomonas aeruginosa HCN + CO2 + ?
-
 ?
1.4.99.5 glycine + 2,6-dichlorophenol-indophenol DCIP Pseudomonas aeruginosa 9-D2 HCN + CO2 + ?
-
 ?
1.4.99.5 glycine + 2-(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyl-tetrazolium chloride INT Pseudomonas aeruginosa HCN + CO2 + ?
-
 ?
1.4.99.5 glycine + O2
-
 Pseudomonas aeruginosa HCN + CO2 + H2O
-
 ?
1.4.99.5 glycine + O2
-
 Chromobacterium violaceum HCN + CO2 + H2O
-
 ?
1.4.99.5 glycine + O2
-
 Pseudomonas aeruginosa 9-D2 HCN + CO2 + H2O
-
 ?
1.4.99.5 glycine + O2
-
 Pseudomonas aeruginosa HCN + CO2 + 2 H2O
-
 ?
1.4.99.5 glycine + O2
-
 Chromobacterium violaceum HCN + CO2 + 2 H2O
-
 ?
1.4.99.5 glycine + phenazine methosulfate PMS provided greatest activity, oxygen allows only a limited response Pseudomonas aeruginosa HCN + CO2 + ?
-
 ?
1.4.99.5 glycine + phenazine methosulfate PMS provided greatest activity, oxygen allows only a limited response Pseudomonas aeruginosa 9-D2 HCN + CO2 + ?
-
 ?
1.4.99.5 glycine + potassium ferricyanide
-
 Pseudomonas aeruginosa HCN + CO2 + ?
-
 ?
1.4.99.5 glycine + potassium ferricyanide
-
 Pseudomonas aeruginosa 9-D2 HCN + CO2 + ?
-
 ?
1.4.99.5 glycine + pyocyanine
-
 Pseudomonas aeruginosa HCN + ?
-
 ?
1.4.99.5 additional information sodium nitrate, sodium nitrite, NAD+, NADP+, FAD and FMN fail as electron acceptors to support cyanide biosynthesis Pseudomonas aeruginosa ?
-
 ?
1.4.99.5 additional information sodium nitrate, sodium nitrite, NAD+, NADP+, FAD and FMN fail as electron acceptors to support cyanide biosynthesis Pseudomonas aeruginosa 9-D2 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.99.5 cyanogenic enzyme system
-
 Pseudomonas aeruginosa
1.4.99.5 HCA
-
 Pseudomonas aeruginosa
1.4.99.5 HCS
-
 Pseudomonas aeruginosa