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Literature summary extracted from

  • Suzuki, O.; Matsumoto, T.
    Purification and properties of diamine oxidase from human kidney (1987), Biogenic Amines, 4, 237-245.
No PubMed abstract available

General Stability

EC Number General Stability Organism
1.4.3.22 unstable in dilute solution or in frozen state Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.22 8-hydroxyquinoline 1 mM, 49.3% inhibition Homo sapiens
1.4.3.22 aminoguanidine 1 mM, complete inhibition Homo sapiens
1.4.3.22 Cuprizone
-
 Homo sapiens
1.4.3.22 cyanide 1 mM, 76% inhibition Homo sapiens
1.4.3.22 diethyldithiocarbamate 1 mM, complete inhibition Homo sapiens
1.4.3.22 additional information not inhibited by pargyline Homo sapiens
1.4.3.22 NaN3
-
 Homo sapiens
1.4.3.22 Quinacrine 1 mM, complete inhibition Homo sapiens
1.4.3.22 Semicarbazide 1 mM, complete inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.22 0.0172
-
 histamine
-
 Homo sapiens
1.4.3.22 0.0279
-
 cadaverine
-
 Homo sapiens
1.4.3.22 0.033
-
 putrescine
-
 Homo sapiens
1.4.3.22 0.625
-
 N1-acetylspermidine
-
 Homo sapiens
1.4.3.22 3.28
-
 N-acetylcadaverine
-
 Homo sapiens
1.4.3.22 5.71
-
 spermine
-
 Homo sapiens
1.4.3.22 9.52
-
 spermidine
-
 Homo sapiens
1.4.3.22 9.71
-
 acetylputrescine
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.22 105000
-
 2 * 105000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.22 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.22 affinity chromatography on AH-Sepharose Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.22 kidney
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.22 0.73
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
1.4.3.22 500 mM ammonium sulfate, 500 mM potassium phosphate, pH 7.4, stable for at least 3 weeks Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.22 1,3-diaminopropane + H2O + O2 109% of activity with putrescine Homo sapiens 3-aminopropanal + NH3 + H2O2
-
 ?
1.4.3.22 1,4-diaminobutane + H2O + O2
-
 Homo sapiens 4-aminobutanal + NH3 + H2O2
-
 ?
1.4.3.22 1,5-diaminopentane + H2O + O2 most active Homo sapiens 5-aminopentanal + NH3 + H2O2
-
 ?
1.4.3.22 1,6-diaminohexane + H2O + O2
-
 Homo sapiens 6-aminohexanal + NH3 + H2O2
-
 ?
1.4.3.22 1,7-diaminoheptane + H2O + O2
-
 Homo sapiens 7-aminoheptanal + NH3 + H2O2
-
 ?
1.4.3.22 agmatine 14% of activity with putrescine Homo sapiens ?
-
 ?
1.4.3.22 histamine + H2O + O2 28% of activity with putrescine Homo sapiens (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 N-acetyl-1,4-diaminobutane + H2O + O2 8.6% of activity with putrescine Homo sapiens N-acetyl-aminobutanal + acetylamine + H2O2
-
 ?
1.4.3.22 N-acetyl-1,5-diaminopentane + H2O + O2 3.8% of activity with putrescine Homo sapiens N-acetyl-aminopentanal + acetylamine + H2O2
-
 ?
1.4.3.22 N-acetylcadaverine + H2O + O2
-
 Homo sapiens ?
-
 r
1.4.3.22 N1-acetyl-spermidine + H2O + O2 8.6% of activity with putrescine Homo sapiens ?
-
 ?
1.4.3.22 RCH2NH2 + H2O + O2
-
 Homo sapiens RCHO + NH3 + H2O2
-
 ?
1.4.3.22 spermidine + H2O + O2
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.22 dimer 2 * 105000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.22 6 6.5 histane Homo sapiens
1.4.3.22 6.5
-
 putrescine and cadaverine Homo sapiens
1.4.3.22 8
-
 N1-acetylspermidine Homo sapiens
1.4.3.22 8.5
-
 acetylcadaverine Homo sapiens
1.4.3.22 9.5
-
 spermidine and spermine Homo sapiens
1.4.3.22 10 11 acetylputrescine Homo sapiens