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Literature summary extracted from

  • Dixon, M.; Kleppe, K.
    D-Amino acid oxidase II. specificity, competitive inhibition and reaction sequence (1965), Biochim. Biophys. Acta, 96, 368-382.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 2-Hydroxy acids
-
 Sus scrofa
1.4.3.3 2-oxo acids
-
 Sus scrofa
1.4.3.3 2-oxobutyrate D-alanine oxidation Sus scrofa
1.4.3.3 aniline slight, D-alanine oxidation Sus scrofa
1.4.3.3 D-2-Hydroxy-3-methylvalerate D-alanine oxidation Sus scrofa
1.4.3.3 D-lactate slight, D-alanine oxidation Sus scrofa
1.4.3.3 DL-2-hydroxybutyrate D-alanine oxidation Sus scrofa
1.4.3.3 DL-2-Hydroxyoctanoate D-alanine oxidation Sus scrofa
1.4.3.3 Glycyl-DL-norvaline slight, D-alanine oxidation Sus scrofa
1.4.3.3 glycyl-DL-phenylalanine slight, D-alanine oxidation Sus scrofa
1.4.3.3 Glycyl-DL-tryptophan slight, D-alanine oxidation Sus scrofa
1.4.3.3 Glycyl-DL-valine slight, D-alanine oxidation Sus scrofa
1.4.3.3 Histidyl-histidine slight, D-alanine oxidation Sus scrofa
1.4.3.3 L-leucine D-alanine oxidation Sus scrofa
1.4.3.3 L-methionine D-alanine oxidation Sus scrofa
1.4.3.3 L-norvaline D-alanine oxidation Sus scrofa
1.4.3.3 Pyrrolidine slight, D-alanine oxidation Sus scrofa
1.4.3.3 pyruvate slight, D-alanine oxidation Sus scrofa
1.4.3.3 Straight-chain fatty acids
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.3 0.015
-
 2,6-dichlorophenolindophenol with D-alanine Sus scrofa
1.4.3.3 0.063
-
 D-Norvaline
-
 Sus scrofa
1.4.3.3 0.067
-
 methylene blue with D-alanine Sus scrofa
1.4.3.3 0.18
-
 O2 with D-alanine Sus scrofa
1.4.3.3 0.4
-
 D-norleucine
-
 Sus scrofa
1.4.3.3 0.46
-
 D-2-aminobutyrate
-
 Sus scrofa
1.4.3.3 0.83
-
 D-methionine
-
 Sus scrofa
1.4.3.3 1.4
-
 D-valine
-
 Sus scrofa
1.4.3.3 1.7
-
 D-proline
-
 Sus scrofa
1.4.3.3 1.8
-
 D-alanine
-
 Sus scrofa
1.4.3.3 1.99
-
 thiazolidine-2-carboxylate
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-2-aminobutyrate + H2O + O2 Sus scrofa
-
 2-oxobutyrate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2 Sus scrofa
-
 pyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-histidine + H2O + O2 Sus scrofa
-
 3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-methionine + H2O + O2 Sus scrofa
-
 4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-norleucine + H2O + O2 Sus scrofa
-
 2-oxohexanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-norvaline + H2O + O2 Sus scrofa
-
 2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-ornithine + H2O + O2 Sus scrofa
-
 5-amino-2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-proline + H2O + O2 Sus scrofa
-
 2-oxopentanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-valine + H2O + O2 Sus scrofa
-
 alpha-ketoisovaleric acid + NH3 + H2O2
-
 ?
1.4.3.3 thiazolidine-2-carboxylic acid + H2O + O2 Sus scrofa
-
 ? + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-2-aminobutyrate + H2O + O2
-
 Sus scrofa 2-oxobutyrate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + 2,6-dichlorophenolindophenol + H2O
-
 Sus scrofa pyruvate + reduced 2,6-dichlorophenolindophenol + H2O2
-
 r
1.4.3.3 D-alanine + H2O + O2
-
 Sus scrofa pyruvic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + oxidized methylene blue + H2O
-
 Sus scrofa pyruvate + reduced methylene blue + H2O2
-
 r
1.4.3.3 D-histidine + H2O + O2
-
 Sus scrofa 3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-methionine + H2O + O2
-
 Sus scrofa 4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-norleucine + H2O + O2
-
 Sus scrofa 2-oxohexanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-norvaline + H2O + O2
-
 Sus scrofa 2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-ornithine + H2O + O2
-
 Sus scrofa 5-amino-2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-proline + H2O + O2
-
 Sus scrofa 2-oxopentanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-valine + H2O + O2
-
 Sus scrofa alpha-ketoisovaleric acid + NH3 + H2O2
-
 ?
1.4.3.3 thiazolidine-2-carboxylic acid + H2O + O2
-
 Sus scrofa ? + NH3 + H2O2
-
 ?