Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Peterson, K.L.; Sergienko, E.E.; Wu, Y.; Kumar, N.R.; Strauss, A.W.; Oleson, A.E.; Muhonen, W.W.; Shabb, J.B.; Srivastava, D.K.
    Recombinant human liver medium-chain acyl-CoA dehydrogenase: purification, characterization, and the mechanism of interactions with functionally diverse C8-CoA molecules (1995), Biochemistry, 34, 14942-14953.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.8.7 expression in Escherichia coli Homo sapiens
1.3.8.7 expression in Escherichia coli Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.8.7 2-octynoyl-CoA
-
 Homo sapiens
1.3.8.7 2-octynoyl-CoA
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.8.7 0.00049
-
 indolepropionyl-CoA oxidase reaction Sus scrofa
1.3.8.7 0.00094
-
 decanoyl-CoA
-
 Sus scrofa
1.3.8.7 0.0023
-
 octanoyl-CoA
-
 Sus scrofa
1.3.8.7 0.0029
-
 decanoyl-CoA
-
 Homo sapiens
1.3.8.7 0.003
-
 octanoyl-CoA
-
 Homo sapiens
1.3.8.7 0.0036
-
 hexanoyl-CoA
-
 Sus scrofa
1.3.8.7 0.0068
-
 hexanoyl-CoA
-
 Homo sapiens
1.3.8.7 0.0087
-
 indolepropionyl-CoA
-
 Homo sapiens
1.3.8.7 0.0099
-
 ferrocenium hexafluorophosphate substrate indolepropionyl-CoA Homo sapiens
1.3.8.7 0.01
-
 indolepropionyl-CoA
-
 Sus scrofa
1.3.8.7 0.014
-
 furylpropionyl-CoA
-
 Sus scrofa
1.3.8.7 0.0144
-
 furylpropionyl-CoA
-
 Homo sapiens
1.3.8.7 0.0426
-
 [4-(dimethylamino)phenyl]propionyl-CoA
-
 Homo sapiens
1.3.8.7 0.061
-
 [4-(dimethylamino)phenyl]propionyl-CoA
-
 Sus scrofa
1.3.8.7 0.069
-
 ferrocenium hexafluorophosphate substrate octanoyl-CoA Homo sapiens
1.3.8.7 0.264
-
 butanoyl-CoA
-
 Sus scrofa
1.3.8.7 0.45
-
 butanoyl-CoA
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.8.7 43000
-
 4 * 43000, recombinant enzyme, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.7 Homo sapiens
-
-
-
1.3.8.7 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.8.7 recombinant liver enzyme, DEAE-Sephacel, hydroxyapatite, tandem column-chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.8.7 4.46
-
 substrate indolepropionyl-CoA, ferrocenium hexafluorophosphate as electron carrier Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.7 butanoyl-CoA + acceptor
-
 Homo sapiens crotonyl-CoA + reduced acceptor
-
 ?
1.3.8.7 butanoyl-CoA + acceptor
-
 Sus scrofa crotonyl-CoA + reduced acceptor
-
 ?
1.3.8.7 decanoyl-CoA + ferricenium hexafluorophosphate
-
 Sus scrofa 2-decenoyl-CoA + ferrocenium hexafluorophosphate
-
 r
1.3.8.7 decanoyl-CoA + ferrocenium hexafluorophosphate
-
 Sus scrofa trans-dec-2-enoyl-CoA + reduced ferrocenium hexafluorophosphate
-
 r
1.3.8.7 furylpropionyl-CoA + ferricenium hexafluorophosphate
-
 Homo sapiens furylacryloyl-CoA + ferrocenium hexafluorophosphate
-
 ?
1.3.8.7 furylpropionyl-CoA + ferricenium hexafluorophosphate
-
 Sus scrofa furylacryloyl-CoA + ferrocenium hexafluorophosphate
-
 ?
1.3.8.7 hexanoyl-CoA + ferricenium hexafluorophosphate
-
 Sus scrofa trans-hex-2-enoyl-CoA + ferrocenium hexafluorophosphate
-
 r
1.3.8.7 hexanoyl-CoA + ferrocenium hexafluorophosphate
-
 Sus scrofa trans-hex-2-enoyl-CoA + reduced ferrocenium hexafluorophosphate
-
 r
1.3.8.7 indolepropionyl-CoA + ferricenium hexafluorophosphate
-
 Homo sapiens indoleacryloyl-CoA + ferrocenium hexafluorophosphate
-
 ?
1.3.8.7 indolepropionyl-CoA + ferricenium hexafluorophosphate
-
 Sus scrofa indoleacryloyl-CoA + ferrocenium hexafluorophosphate
-
 ?
1.3.8.7 indolepropionyl-CoA + O2 very low activity Homo sapiens indoleacryloyl-CoA + H2O2
-
 ?
1.3.8.7 indolepropionyl-CoA + O2 very low activity Sus scrofa indoleacryloyl-CoA + H2O2
-
 ?
1.3.8.7 [4-(dimethylamino)phenyl]propionyl-CoA + ferricenium hexafluorophosphate
-
 Homo sapiens 4-(dimethylamino)cinnamoyl-CoA + ferrocenium hexafluorophosphate
-
 ?
1.3.8.7 [4-(dimethylamino)phenyl]propionyl-CoA + ferricenium hexafluorophosphate
-
 Sus scrofa 4-(dimethylamino)cinnamoyl-CoA + ferrocenium hexafluorophosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.8.7 tetramer
-
 Sus scrofa
1.3.8.7 tetramer 4 * 43000, recombinant enzyme, SDS-PAGE Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.8.7 0.016
-
 indolepropionyl-CoA oxidase reaction Sus scrofa
1.3.8.7 0.46
-
 indolepropionyl-CoA
-
 Sus scrofa
1.3.8.7 0.61
-
 [4-(dimethylamino)phenyl]propionyl-CoA
-
 Sus scrofa
1.3.8.7 3.4
-
 indolepropionyl-CoA
-
 Homo sapiens
1.3.8.7 4.6
-
 [4-(dimethylamino)phenyl]propionyl-CoA
-
 Homo sapiens
1.3.8.7 6.2
-
 butanoyl-CoA
-
 Sus scrofa
1.3.8.7 7.4
-
 decanoyl-CoA
-
 Homo sapiens
1.3.8.7 8.6
-
 decanoyl-CoA
-
 Sus scrofa
1.3.8.7 11.5
-
 butanoyl-CoA
-
 Homo sapiens
1.3.8.7 13.2
-
 furylpropionyl-CoA
-
 Sus scrofa
1.3.8.7 13.6
-
 furylpropionyl-CoA
-
 Homo sapiens
1.3.8.7 14.2
-
 hexanoyl-CoA
-
 Homo sapiens
1.3.8.7 19.2
-
 octanoyl-CoA
-
 Homo sapiens
1.3.8.7 19.6
-
 octanoyl-CoA
-
 Sus scrofa
1.3.8.7 20.6
-
 hexanoyl-CoA
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.8.7 0.00036
-
 2-octynoyl-CoA competitive vs. indolepropionyl-CoA Homo sapiens