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Literature summary extracted from

  • Lancaster, C.R.D.
    Succinate: quinone oxidoreductases - what can we learn from Wolinella succinogenes quinol:fumarate reductase? (2001), FEBS Lett., 504, 133-141.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.5.1 fumarate reductase, determined at 3.3 A, belongs to the type D enzymes: contains two hydrophobic subunits and no heme group Escherichia coli
1.3.5.1 fumarate reductase, refined at 2.2-A resolution, belongs to the type B enzymes: contains one hydrophobic subunit and two heme groups Wolinella succinogenes

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.5.1 27000
-
 1 * 73000 + 1 * 27000 + 1 * 30000, three structures of the enzyme based on three different crystal forms are available, in all three crystal forms two heterotrimeric complexes of A,B and C subunits are associated in an identical fashion, forming a dimer Wolinella succinogenes
1.3.5.1 30000
-
 1 * 73000 + 1 * 27000 + 1 * 30000, three structures of the enzyme based on three different crystal forms are available, in all three crystal forms two heterotrimeric complexes of A,B and C subunits are associated in an identical fashion, forming a dimer Wolinella succinogenes
1.3.5.1 73000
-
 1 * 73000 + 1 * 27000 + 1 * 30000, three structures of the enzyme based on three different crystal forms are available, in all three crystal forms two heterotrimeric complexes of A,B and C subunits are associated in an identical fashion, forming a dimer Wolinella succinogenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.1 additional information Wolinella succinogenes succinate dehydrogenase is involved in aerobic metabolism as part of the citric acid cycle and of the aerobic respiratory chain, fumarate reductase participates in anaerobic respiration with fumarate as the terminal electron acceptor and is part of the electron transport chain catalysing the oxidation of various donor substrates by fumarate ?
-
 ?
1.3.5.1 succinate + ubiquinone Escherichia coli
-
 fumarate + ubiquinol
-
 r
1.3.5.1 succinate + ubiquinone Wolinella succinogenes
-
 fumarate + ubiquinol
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Escherichia coli
-
 fumarate reductase
-
1.3.5.1 Wolinella succinogenes
-
 succinate dehydrogenase
-
1.3.5.1 Wolinella succinogenes
-
 formerly Vibrio succinogenes, fumarate reductase
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 fumarate + quinol
-
 Escherichia coli succinate + ubiquinone
-
 r
1.3.5.1 fumarate + quinol
-
 Wolinella succinogenes succinate + ubiquinone
-
 r
1.3.5.1 additional information succinate dehydrogenase is involved in aerobic metabolism as part of the citric acid cycle and of the aerobic respiratory chain, fumarate reductase participates in anaerobic respiration with fumarate as the terminal electron acceptor and is part of the electron transport chain catalysing the oxidation of various donor substrates by fumarate Wolinella succinogenes ?
-
 ?
1.3.5.1 succinate + ubiquinone
-
 Escherichia coli fumarate + ubiquinol
-
 r
1.3.5.1 succinate + ubiquinone
-
 Wolinella succinogenes fumarate + ubiquinol
-
 r

Subunits

EC Number Subunits Comment Organism
1.3.5.1 trimer 1 * 73000 + 1 * 27000 + 1 * 30000, three structures of the enzyme based on three different crystal forms are available, in all three crystal forms two heterotrimeric complexes of A,B and C subunits are associated in an identical fashion, forming a dimer Wolinella succinogenes

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.5.1 cytochrome b
-
 Escherichia coli
1.3.5.1 cytochrome b
-
 Wolinella succinogenes
1.3.5.1 FAD covalently bound to flavoprotein subunit Escherichia coli
1.3.5.1 FAD covalently bound to flavoprotein subunit Wolinella succinogenes
1.3.5.1 additional information the enzyme contains iron-sulfur centers Escherichia coli
1.3.5.1 additional information the enzyme contains iron-sulfur centers Wolinella succinogenes