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Literature summary extracted from

  • Maklashina, E.; Cecchini, G.
    Comparison of catalytic activity and inhibitors of quinone reactions of succinate dehydrogenase (Succinate-ubiquinone oxidoreductase) and fumarate reductase (Menaquinol-fumarate oxidoreductase) from Escherichia coli (1999), Arch. Biochem. Biophys., 369, 223-232.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.1 2-(n-heptyl)-4-hydroxy-quinoline N-oxide potent inhibitor of fumarate reductase, not inhibitory for succinate dehydrogenase Escherichia coli
1.3.5.1 2-alkyl-4,6-dinitrophenol-17
-
Escherichia coli
1.3.5.1 2-alkyl-4,6-dinitrophenol-20
-
Escherichia coli
1.3.5.1 2-alkyl-4,6-dinitrophenols derivatives of 2-alkyl-4,6-dinitrophenols, competitive inhibitors of both succinate dehydrogenase and fumarate reductase Escherichia coli
1.3.5.1 carboxin inhibits the succinate dehydrogenase in the forward and reverse reaction Escherichia coli
1.3.5.1 malonate inhibits both succinate dehydrogenase and fumarate reductase Escherichia coli
1.3.5.1 menaquinone-1 competitive inhibitor of the succinate oxidation reaction of succinate dehydrogenase Escherichia coli
1.3.5.1 Pentachlorophenol competitive inhibitor of both succinate dehydrogenase and fumarate reductase Escherichia coli
1.3.5.1 ubiquinol-2 competitive inhibitor of the fumarate reduction reaction of fumarate reductase Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.5.1 additional information
-
additional information succinate-quinone and quinol-fumarate reductase reaction of succinate dehydrogenase and fumarate reductase Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.1 membrane
-
Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.1 fumarate + menaquinol Escherichia coli fumarate reductase acts as part of an anaerobic respiratory chain succinate + menaquinone
-
r
1.3.5.1 additional information Escherichia coli succinate dehydrogenase is a component of the respiratory chain and operates as a compulsory member of the Krebs cycle in mammals ?
-
?
1.3.5.1 succinate + ubiquinone Escherichia coli
-
fumarate + ubiquinol
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Escherichia coli
-
succinate dehydrogenase
-
1.3.5.1 Escherichia coli
-
fumarate reductase
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.5.1 of both succinate dehydrogenase and fumarate reductase using solubilization with Thesit and DEAE fast-flow chromatography Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 fumarate + menaquinol fumarate reductase acts as part of an anaerobic respiratory chain Escherichia coli succinate + menaquinone
-
r
1.3.5.1 fumarate + quinol
-
Escherichia coli succinate + ubiquinone
-
r
1.3.5.1 additional information succinate dehydrogenase is a component of the respiratory chain and operates as a compulsory member of the Krebs cycle in mammals Escherichia coli ?
-
?
1.3.5.1 succinate + ubiquinone
-
Escherichia coli fumarate + ubiquinol
-
r

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.5.1 additional information
-
additional information succinate-quinone and quinol-fumarate reductase reaction of succinate dehydrogenase and fumarate reductase Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.5.1 7.4 7.8 for both succinate dehydrogenase and fumarate reductase Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.5.1 0.000075
-
2-(n-heptyl)-4-hydroxy-quinoline N-oxide fumarate reductase, succinate oxidation reaction Escherichia coli
1.3.5.1 0.0002
-
2-(n-heptyl)-4-hydroxy-quinoline N-oxide fumarate reductase, fumarate reduction reaction Escherichia coli
1.3.5.1 0.0013
-
2-alkyl-4,6-dinitrophenol-17 fumarate reductase, succinate oxidation reaction Escherichia coli
1.3.5.1 0.0015
-
2-alkyl-4,6-dinitrophenol-20 fumarate reductase, succinate oxidation reaction Escherichia coli
1.3.5.1 0.002
-
2-alkyl-4,6-dinitrophenol-17 fumarate reductase, fumarate reduction reaction Escherichia coli
1.3.5.1 0.002
-
2-alkyl-4,6-dinitrophenol-20 fumarate reductase, fumarate reduction reaction Escherichia coli
1.3.5.1 0.012
-
menaquinone-1 succinate dehydrogenase, succinate oxidation reaction Escherichia coli
1.3.5.1 0.013
-
Pentachlorophenol succinate dehydrogenase, succinate oxidation reaction Escherichia coli
1.3.5.1 0.015
-
ubiquinol-2 fumarate reductase, fumarate reduction reaction Escherichia coli
1.3.5.1 0.017
-
2-alkyl-4,6-dinitrophenol-17 succinate dehydrogenase, succinate oxidation reaction Escherichia coli
1.3.5.1 0.017
-
Pentachlorophenol succinate dehydrogenase, fumarate reduction reaction Escherichia coli
1.3.5.1 0.019
-
2-alkyl-4,6-dinitrophenol-20 succinate dehydrogenase, succinate oxidation reaction Escherichia coli
1.3.5.1 0.023
-
Pentachlorophenol fumarate reductase, succinate oxidation reaction Escherichia coli
1.3.5.1 0.03
-
carboxin succinate dehydrogenase, succinate oxidation reaction Escherichia coli
1.3.5.1 0.035
-
carboxin succinate dehydrogenase, fumarate reduction reaction Escherichia coli
1.3.5.1 0.037
-
Pentachlorophenol fumarate reductase, fumarate reduction reaction Escherichia coli