Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Poulson, R.; Polglase, W.J.
    The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX. Protoporphyrinogen oxidase activity in mitochondrial extracts of Saccharomyces cerevisiae (1975), J. Biol. Chem., 250, 1269-1274.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.3.4 cysteine
-
Saccharomyces cerevisiae
1.3.3.4 dithiothreitol
-
Saccharomyces cerevisiae
1.3.3.4 glutathione
-
Saccharomyces cerevisiae

General Stability

EC Number General Stability Organism
1.3.3.4 sensitive towards trypsin and chymotrypsin Saccharomyces cerevisiae
1.3.3.4 stable on dialysis Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.4 arsenite slight inhibition Saccharomyces cerevisiae
1.3.3.4 Co2+ inhibitory Saccharomyces cerevisiae
1.3.3.4 Cu2+ inhibitory Saccharomyces cerevisiae
1.3.3.4 heme noncompetitive, reversible by dilution Saccharomyces cerevisiae
1.3.3.4 hemin noncompetitive, reversible by dilution Saccharomyces cerevisiae
1.3.3.4 iodoacetamide slight inhibition Saccharomyces cerevisiae
1.3.3.4 iodoacetate slight inhibition Saccharomyces cerevisiae
1.3.3.4 additional information inhibited by high salt concentrations Saccharomyces cerevisiae
1.3.3.4 p-hydroxymercuribenzoate
-
Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.3.4 0.0048
-
protoporphyrinogen-IX
-
Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.3.4 mitochondrion
-
Saccharomyces cerevisiae 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.3.4 180000
-
gel filtration Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.4 protoporphyrinogen-IX + 3 O2 Saccharomyces cerevisiae penultimate step of heme and chlorophyll biosynthesis protoporphyrin-IX + 3 H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.4 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.3.4
-
Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.3.4 0.0026
-
purified enzyme Saccharomyces cerevisiae

Storage Stability

EC Number Storage Stability Organism
1.3.3.4 -20°C, in 50 mM Tris-HCl in presence of 20% glycerol and 1 mM EDTA, several months, no loss of activity Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.4 mesoporphyrinogen-IX + 3 O2 20% of the rate of protoporphyrinogen-IX Saccharomyces cerevisiae mesoporphyrin-IX + 3 H2O2
-
?
1.3.3.4 protoporphyrinogen-IX + 3 O2
-
Saccharomyces cerevisiae protoporphyrin-IX + 3 H2O2
-
?
1.3.3.4 protoporphyrinogen-IX + 3 O2 penultimate step of heme and chlorophyll biosynthesis Saccharomyces cerevisiae protoporphyrin-IX + 3 H2O2
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.3.3.4 40
-
inactivated above 40°C Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.3.4 7.5
-
-
Saccharomyces cerevisiae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.3.3.4 6.5 9
-
Saccharomyces cerevisiae

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.3.3.4 4 9.5 unstable at higher and lower pH Saccharomyces cerevisiae