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Literature summary extracted from

  • Loeffler, M.; Becker, C.; Wegerle, E.; Schuster, G.
    Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria (1996), Histochem. Cell Biol., 105, 119-128.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.2 brequinar sodium complete activity termination in all tissues at 0.01 mM Bos taurus
1.3.5.2 brequinar sodium complete activity termination in all tissues at 0.01 mM Cavia porcellus
1.3.5.2 brequinar sodium complete activity termination in all tissues at 0.01 mM Homo sapiens
1.3.5.2 brequinar sodium complete activity termination in all tissues at 0.01 mM Mus musculus
1.3.5.2 brequinar sodium complete activity termination in all tissues at 0.01 mM Rattus norvegicus
1.3.5.2 brequinar sodium complete activity termination in all tissues at 0.01 mM Sus scrofa
1.3.5.2 Orotate
-
Bos taurus
1.3.5.2 Orotate
-
Cavia porcellus
1.3.5.2 Orotate
-
Mus musculus
1.3.5.2 Orotate
-
Rattus norvegicus
1.3.5.2 Orotate
-
Sus scrofa
1.3.5.2 toltrazuril 50% inhibition at 0.1 mM Bos taurus
1.3.5.2 toltrazuril 50% inhibition at 0.1 mM Cavia porcellus
1.3.5.2 toltrazuril 50% inhibition at 0.1 mM Homo sapiens
1.3.5.2 toltrazuril 50% inhibition at 0.1 mM Mus musculus
1.3.5.2 toltrazuril 50% inhibition at 0.1 mM Rattus norvegicus
1.3.5.2 toltrazuril 50% inhibition at 0.1 mM Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.2 mitochondrion inner membrane Cavia porcellus 5739
-
1.3.5.2 mitochondrion inner membrane Mus musculus 5739
-
1.3.5.2 mitochondrion inner membrane Homo sapiens 5739
-
1.3.5.2 mitochondrion inner membrane Sus scrofa 5739
-
1.3.5.2 mitochondrion inner membrane Bos taurus 5739
-
1.3.5.2 mitochondrion inner membrane Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.2 (S)-dihydroorotate + ubiquinone Cavia porcellus
-
orotate + ubiquinol
-
ir
1.3.5.2 (S)-dihydroorotate + ubiquinone Sus scrofa
-
orotate + ubiquinol
-
ir
1.3.5.2 (S)-dihydroorotate + ubiquinone Bos taurus
-
orotate + ubiquinol
-
ir
1.3.5.2 (S)-dihydroorotate + ubiquinone Mus musculus fourth enzyme in pyrimidine synthesis orotate + ubiquinol
-
ir
1.3.5.2 (S)-dihydroorotate + ubiquinone Homo sapiens fourth enzyme in pyrimidine synthesis orotate + ubiquinol
-
ir
1.3.5.2 (S)-dihydroorotate + ubiquinone Rattus norvegicus fourth enzyme in pyrimidine synthesis orotate + ubiquinol
-
ir

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.2 Bos taurus
-
-
-
1.3.5.2 Cavia porcellus
-
-
-
1.3.5.2 Homo sapiens
-
-
-
1.3.5.2 Mus musculus
-
-
-
1.3.5.2 Rattus norvegicus Q63707
-
-
1.3.5.2 Rattus norvegicus Q63707 Wistar rats, both sexes, 6 month
-
1.3.5.2 Sus scrofa
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.5.2 (S)-dihydroorotate + a quinone = orotate + a quinol in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity Cavia porcellus
1.3.5.2 (S)-dihydroorotate + a quinone = orotate + a quinol in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity Mus musculus
1.3.5.2 (S)-dihydroorotate + a quinone = orotate + a quinol in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity Homo sapiens
1.3.5.2 (S)-dihydroorotate + a quinone = orotate + a quinol in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity Sus scrofa
1.3.5.2 (S)-dihydroorotate + a quinone = orotate + a quinol in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity Bos taurus
1.3.5.2 (S)-dihydroorotate + a quinone = orotate + a quinol in liver, myocardium and skeletal muscle tissues the activity intensities vary from animal to animal, but are similar in ileum, colon and kidney cortex. Cardiac enzyme expresses a pronounced oxidase activity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.5.2 colon
-
Rattus norvegicus
-
1.3.5.2 Ehrlich ascites carcinoma cell
-
Mus musculus
-
1.3.5.2 gland
-
Rattus norvegicus
-
1.3.5.2 heart
-
Sus scrofa
-
1.3.5.2 heart
-
Bos taurus
-
1.3.5.2 heart
-
Rattus norvegicus
-
1.3.5.2 ileum
-
Rattus norvegicus
-
1.3.5.2 intestine
-
Rattus norvegicus
-
1.3.5.2 kidney
-
Cavia porcellus
-
1.3.5.2 kidney
-
Homo sapiens
-
1.3.5.2 kidney
-
Sus scrofa
-
1.3.5.2 kidney
-
Rattus norvegicus
-
1.3.5.2 liver
-
Homo sapiens
-
1.3.5.2 liver
-
Sus scrofa
-
1.3.5.2 liver
-
Rattus norvegicus
-
1.3.5.2 lung
-
Rattus norvegicus
-
1.3.5.2 additional information distribution in various tissues Homo sapiens
-
1.3.5.2 additional information distribution in various tissues Rattus norvegicus
-
1.3.5.2 reproductive system
-
Rattus norvegicus
-
1.3.5.2 skeletal muscle
-
Rattus norvegicus
-
1.3.5.2 skin
-
Homo sapiens
-
1.3.5.2 skin
-
Rattus norvegicus
-
1.3.5.2 stomach
-
Rattus norvegicus
-
1.3.5.2 trachea
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.5.2 additional information
-
highest activities in ileum and colon Rattus norvegicus
1.3.5.2 0.0026
-
liver Sus scrofa
1.3.5.2 0.0026
-
kidney Cavia porcellus
1.3.5.2 0.0054
-
liver Rattus norvegicus
1.3.5.2 0.0054
-
kidney Sus scrofa
1.3.5.2 0.0066
-
heart Bos taurus
1.3.5.2 0.0078
-
heart Sus scrofa
1.3.5.2 0.015
-
EAT cells Mus musculus

Storage Stability

EC Number Storage Stability Organism
1.3.5.2 -80°C, slight activity loss after freezing and storage Cavia porcellus
1.3.5.2 -80°C, slight activity loss after freezing and storage Mus musculus
1.3.5.2 -80°C, slight activity loss after freezing and storage Homo sapiens
1.3.5.2 -80°C, slight activity loss after freezing and storage Sus scrofa
1.3.5.2 -80°C, slight activity loss after freezing and storage Bos taurus
1.3.5.2 -80°C, slight activity loss after freezing and storage Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.2 (S)-dihydroorotate + ubiquinone
-
Cavia porcellus orotate + ubiquinol
-
ir
1.3.5.2 (S)-dihydroorotate + ubiquinone
-
Sus scrofa orotate + ubiquinol
-
ir
1.3.5.2 (S)-dihydroorotate + ubiquinone
-
Bos taurus orotate + ubiquinol
-
ir
1.3.5.2 (S)-dihydroorotate + ubiquinone fourth enzyme in pyrimidine synthesis Mus musculus orotate + ubiquinol
-
ir
1.3.5.2 (S)-dihydroorotate + ubiquinone fourth enzyme in pyrimidine synthesis Homo sapiens orotate + ubiquinol
-
ir
1.3.5.2 (S)-dihydroorotate + ubiquinone fourth enzyme in pyrimidine synthesis Rattus norvegicus orotate + ubiquinol
-
ir
1.3.5.2 dihydroorotate + acceptor
-
Homo sapiens orotate + reduced acceptor
-
?
1.3.5.2 dihydroorotate + acceptor
-
Rattus norvegicus orotate + reduced acceptor
-
?