BRENDA - Enzyme Database

Purification and enzymatic activity of an NADH-fumarate reductase and other mitochondrial activities of Leishmania parasites

Chen, M.; Bennedsen, M.; Zhai, L.; Kharazmi, A.; APMIS 109, 801-808 (2001)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
1.3.1.6
medicine
might serve as target for anti-Leishmania drugs
Leishmania donovani
1.3.1.6
medicine
might serve as target for anti-Leishmania drugs
Leishmania major
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.3.1.6
Cu2+
-
Leishmania donovani
1.3.1.6
Cu2+
-
Leishmania major
1.3.1.6
malonate
-
Leishmania donovani
1.3.1.6
Zn2+
strong inhibitor
Leishmania donovani
1.3.1.6
Zn2+
strong inhibitor
Leishmania major
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.3.1.6
membrane
-
Leishmania donovani
16020
-
1.3.1.6
mitochondrion
-
Leishmania major
5739
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.3.1.6
65000
-
-
Leishmania donovani
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.3.1.6
fumarate + NADH + H+
Leishmania donovani
component of respiratory chain
succinate + NAD+
-
Leishmania donovani
-
1.3.1.6
fumarate + NADH + H+
Leishmania major
component of respiratory chain
succinate + NAD+
-
Leishmania major
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.3.1.6
Leishmania donovani
-
-
-
1.3.1.6
Leishmania major
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.3.1.6
-
Leishmania donovani
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.3.1.6
amastigote
-
Leishmania donovani
-
1.3.1.6
promastigote
-
Leishmania major
-
1.3.1.6
promastigote
-
Leishmania donovani
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.3.1.6
2189
-
purified enzyme from promastigotes
Leishmania donovani
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.3.1.6
fumarate + NADH + H+
-
390843
Leishmania donovani
succinate + NAD+
-
390843
Leishmania donovani
?
1.3.1.6
fumarate + NADH + H+
-
390843
Leishmania major
succinate + NAD+
-
390843
Leishmania major
?
1.3.1.6
fumarate + NADH + H+
component of respiratory chain
390843
Leishmania donovani
succinate + NAD+
-
390843
Leishmania donovani
-
1.3.1.6
fumarate + NADH + H+
component of respiratory chain
390843
Leishmania major
succinate + NAD+
-
390843
Leishmania major
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.3.1.6
NADH
-
Leishmania donovani
1.3.1.6
NADH
-
Leishmania major
Application (protein specific)
EC Number
Application
Commentary
Organism
1.3.1.6
medicine
might serve as target for anti-Leishmania drugs
Leishmania donovani
1.3.1.6
medicine
might serve as target for anti-Leishmania drugs
Leishmania major
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.3.1.6
NADH
-
Leishmania donovani
1.3.1.6
NADH
-
Leishmania major
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.3.1.6
Cu2+
-
Leishmania donovani
1.3.1.6
Cu2+
-
Leishmania major
1.3.1.6
malonate
-
Leishmania donovani
1.3.1.6
Zn2+
strong inhibitor
Leishmania donovani
1.3.1.6
Zn2+
strong inhibitor
Leishmania major
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.3.1.6
membrane
-
Leishmania donovani
16020
-
1.3.1.6
mitochondrion
-
Leishmania major
5739
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.3.1.6
65000
-
-
Leishmania donovani
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.3.1.6
fumarate + NADH + H+
Leishmania donovani
component of respiratory chain
succinate + NAD+
-
Leishmania donovani
-
1.3.1.6
fumarate + NADH + H+
Leishmania major
component of respiratory chain
succinate + NAD+
-
Leishmania major
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.3.1.6
-
Leishmania donovani
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.3.1.6
amastigote
-
Leishmania donovani
-
1.3.1.6
promastigote
-
Leishmania major
-
1.3.1.6
promastigote
-
Leishmania donovani
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.3.1.6
2189
-
purified enzyme from promastigotes
Leishmania donovani
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.3.1.6
fumarate + NADH + H+
-
390843
Leishmania donovani
succinate + NAD+
-
390843
Leishmania donovani
?
1.3.1.6
fumarate + NADH + H+
-
390843
Leishmania major
succinate + NAD+
-
390843
Leishmania major
?
1.3.1.6
fumarate + NADH + H+
component of respiratory chain
390843
Leishmania donovani
succinate + NAD+
-
390843
Leishmania donovani
-
1.3.1.6
fumarate + NADH + H+
component of respiratory chain
390843
Leishmania major
succinate + NAD+
-
390843
Leishmania major
-