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Literature summary extracted from
- Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase (2001), J. Biol. Chem., 276, 40803-40810.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.3.1.48 | expression in Escherichia coli | Rattus norvegicus |
| 1.3.1.74 | - |
Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.74 | cyclovalone | - |
Rattus norvegicus |  |
| 1.3.1.74 | progesterone | - |
Rattus norvegicus | |
| 1.3.1.74 | quercetin | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.3.1.48 | 0.001 | - |
15-ketoprostaglandin E1 | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.016 | - |
3-nonen-2-one | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.039 | - |
benzylidene acetone | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.04 | - |
trans-2-decenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.046 | - |
trans-2-nonenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.06 | - |
trans-2-dodecenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.075 | - |
cinnamaldehyde | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.11 | - |
ethylvinylketone | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.12 | - |
4-hydroxy-2-nonenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.15 | - |
acrolein | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.18 | - |
chalcone | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.21 | - |
4-hydroxy-2-hexenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.36 | - |
trans-2-octenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.41 | - |
trans,trans-2,4-nonadienal | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.49 | - |
3-penten-2-one | - |
Rattus norvegicus | |
| 1.3.1.48 | 0.58 | - |
methylvinylketone | - |
Rattus norvegicus | |
| 1.3.1.48 | 1 | - |
trans-2-hexenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 1.7 | - |
alpha-methylcinnamaldehyde | - |
Rattus norvegicus | |
| 1.3.1.48 | 2.4 | - |
trans-2-pentenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 3.9 | - |
crotonaldehyde | - |
Rattus norvegicus | |
| 1.3.1.74 | 0.001 | - |
15-oxoprostaglandin E1 | 30°C | Rattus norvegicus | |
| 1.3.1.74 | 0.11 | - |
ethyl vinyl ketone | 30°C | Rattus norvegicus | |
| 1.3.1.74 | 0.12 | - |
4-hydroxy-2-nonenal | 30°C | Rattus norvegicus | |
| 1.3.1.74 | 0.15 | - |
acrolein | 30°C | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.74 | n-alkanal + NAD(P)+ | Rattus norvegicus | role in detoxication | alk-2-enal + NAD(P)H | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.48 | Rattus norvegicus | - |
- |
- |
| 1.3.1.74 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.3.1.48 | recombinant enzyme | Rattus norvegicus |
| 1.3.1.74 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.3.1.74 | liver | - |
Rattus norvegicus | - |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.3.1.74 | -80°C, no loss of activity for 8 months | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.48 | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H | - |
Rattus norvegicus | (5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+ | - |
? | |
| 1.3.1.48 | 15-ketoprostaglandin E1 + NADH + H+ | - |
Rattus norvegicus | 13,14-dihydro-15-ketoprostaglandin E1 + NAD+ | - |
r | |
| 1.3.1.48 | 3-nonen-2-one + NADPH | - |
Rattus norvegicus | nonane-2-one + NADP+ | - |
? | |
| 1.3.1.48 | 3-penten-2-one + NADPH | - |
Rattus norvegicus | pentane-2-one + NADP+ | - |
? | |
| 1.3.1.48 | 4-hydroxy-2-hexenal + NADPH | - |
Rattus norvegicus | 4-hydroxyhexanal + NADP+ | - |
? | |
| 1.3.1.48 | 4-hydroxy-2-nonenal + NADPH | - |
Rattus norvegicus | 4-hydroxynonanal + NADP+ | - |
? | |
| 1.3.1.48 | acrolein + NADPH | - |
Rattus norvegicus | propanal + NADP+ | - |
? | |
| 1.3.1.48 | alpha-methylcinnamaldehyde + NADPH | - |
Rattus norvegicus | ? | - |
? | |
| 1.3.1.48 | chalcone + NADPH | - |
Rattus norvegicus | ? | - |
? | |
| 1.3.1.48 | ethylvinylketone + NADPH | - |
Rattus norvegicus | pentane-3-one + NADP+ | - |
? | |
| 1.3.1.48 | trans,trans-2,4-nonadienal + NADPH + H+ | - |
Rattus norvegicus | ? | - |
r | |
| 1.3.1.48 | trans-2-butenal + NAD(P)H | - |
Rattus norvegicus | butanal + NAD(P)+ | - |
? | |
| 1.3.1.48 | trans-2-decenal + NADPH | - |
Rattus norvegicus | decanal + NADP+ | - |
? | |
| 1.3.1.48 | trans-2-dodecenal + NADPH | - |
Rattus norvegicus | dodecanal + NADP+ | - |
? | |
| 1.3.1.48 | trans-2-hexenal + NAD(P)H | - |
Rattus norvegicus | hexanal + NAD(P)+ | - |
? | |
| 1.3.1.48 | trans-2-nonenal + NADPH | - |
Rattus norvegicus | nonanal + NADP+ | - |
? | |
| 1.3.1.48 | trans-2-octenal + NADPH | - |
Rattus norvegicus | octanal + NADP+ | - |
? | |
| 1.3.1.48 | trans-2-pentenal + NADPH | - |
Rattus norvegicus | pentanal + NADP+ | - |
? | |
| 1.3.1.48 | trans-benzylideneacetone + NAD(P)H | - |
Rattus norvegicus | benzylacetone + NAD(P)+ | - |
? | |
| 1.3.1.48 | trans-cinnamaldehyde + NAD(P)H | - |
Rattus norvegicus | ? | - |
? | |
| 1.3.1.48 | trans-methylvinylketone + NAD(P)H | - |
Rattus norvegicus | butane-2-one + NAD(P)+ | - |
? | |
| 1.3.1.48 | trans-trans-2,4-hexadienal + NAD(P)H | - |
Rattus norvegicus | ? | - |
? | |
| 1.3.1.74 | 15-oxoprostaglandin E1 + NAD(P)H | - |
Rattus norvegicus | ? + NAD(P)+ | - |
? | |
| 1.3.1.74 | 4-hydroxy-(2E)-nonenal + NAD(P)H | - |
Rattus norvegicus | 4-hydroxynonylaldehyde + NAD(P)+ | - |
? | |
| 1.3.1.74 | benzylidine acetone + NAD(P)H | reduction of alpha,beta-double bond | Rattus norvegicus | ? + NAD(P)+ | - |
? | |
| 1.3.1.74 | ethyl vinyl ketone + NAD(P)H | - |
Rattus norvegicus | diethylketone + NAD(P)+ | - |
? | |
| 1.3.1.74 | methyl vinyl ketone + NAD(P)H | - |
Rattus norvegicus | dimethylketone + NAD(P)+ | - |
? | |
| 1.3.1.74 | additional information | reduction of the alpha,beta-carbon-carbon double bond to a single bond, broad substrate specificity | Rattus norvegicus | ? | - |
? | |
| 1.3.1.74 | n-alkanal + NAD(P)+ | - |
Rattus norvegicus | alk-2-enal + NAD(P)H | - |
? | |
| 1.3.1.74 | n-alkanal + NAD(P)+ | role in detoxication | Rattus norvegicus | alk-2-enal + NAD(P)H | - |
? | |
| 1.3.1.74 | propenal + NAD(P)H | synonym: acrolein | Rattus norvegicus | propanal + NAD(P)+ | - |
? | |
| 1.3.1.74 | trans,trans-2,4-alkadienal + NAD(P)H | - |
Rattus norvegicus | ? + NAD(P)+ | - |
? | |
| 1.3.1.74 | trans-2-alkenal + NAD(P)H | - |
Rattus norvegicus | alkanal + NAD(P)+ | - |
? | |
| 1.3.1.74 | trans-4-hydroxy-2-alkenal + NAD(P)H | - |
Rattus norvegicus | 4-hydroxyalkanal + NAD(P)+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.1.48 | NAD(P)H-dependent alkenal/one oxidoreductase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.74 | 30 | - |
assay at | Rattus norvegicus |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.3.1.48 | 3.72 | - |
acrolein | - |
Rattus norvegicus | |
| 1.3.1.48 | 8.05 | - |
crotonaldehyde | - |
Rattus norvegicus | |
| 1.3.1.48 | 13.1 | - |
alpha-methylcinnamaldehyde | - |
Rattus norvegicus | |
| 1.3.1.48 | 13.4 | - |
4-hydroxy-2-hexenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 15.7 | - |
cinnamaldehyde | - |
Rattus norvegicus | |
| 1.3.1.48 | 16.8 | - |
trans-2-pentenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 17.2 | - |
trans,trans-2,4-nonadienal | - |
Rattus norvegicus | |
| 1.3.1.48 | 18.5 | - |
3-penten-2-one | - |
Rattus norvegicus | |
| 1.3.1.48 | 19.8 | - |
3-nonen-2-one | - |
Rattus norvegicus | |
| 1.3.1.48 | 28.8 | - |
trans-2-hexenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 32.3 | - |
chalcone | - |
Rattus norvegicus | |
| 1.3.1.48 | 40 | - |
15-ketoprostaglandin E1 | - |
Rattus norvegicus | |
| 1.3.1.48 | 54.7 | - |
benzylidene acetone | - |
Rattus norvegicus | |
| 1.3.1.48 | 60.2 | - |
trans-2-dodecenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 67.3 | - |
4-hydroxy-2-nonenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 70.8 | - |
trans-2-decenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 89.7 | - |
trans-2-octenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 94.5 | - |
trans-2-nonenal | - |
Rattus norvegicus | |
| 1.3.1.48 | 156 | - |
methylvinylketone | - |
Rattus norvegicus | |
| 1.3.1.48 | 160 | - |
ethylvinylketone | - |
Rattus norvegicus | |
| 1.3.1.74 | 3.67 | - |
acrolein | 30°C | Rattus norvegicus | |
| 1.3.1.74 | 40 | - |
15-oxoprostaglandin E1 | 30°C | Rattus norvegicus | |
| 1.3.1.74 | 66.7 | - |
4-hydroxy-2-nonenal | 30°C | Rattus norvegicus | |
| 1.3.1.74 | 160 | - |
ethyl vinyl ketone | 30°C | Rattus norvegicus | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.74 | NADPH | - |
Rattus norvegicus | |
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