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Literature summary extracted from

  • Cheng, Y.J.; Karavolas, H.J.
    Properties and subcellular distribution of DELTA4-steroid (progesterone) 5alpha-reductase in rat anterior pituitary (1975), Steroids, 26, 57-71.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 17beta-estradiol
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 additional information
-
 additional information
-
 Rattus norvegicus
1.3.1.22 0.00027
-
 progesterone
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 additional information nuclear and cell-debris fraction Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rattus norvegicus
-
 female rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 hypophysis anterior Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 20alpha-hydroxy-4-pregnen-3-one + NADPH more reactive than progesterone Rattus norvegicus 20alpha-hydroxy-5-beta-pregnan-3-one + NADP+
-
 ?
1.3.1.22 additional information testosterone and 20alpha-hydroxy-4-pregnen-3-one can act in place of progesterone Rattus norvegicus ?
-
 ?
1.3.1.22 additional information testosterone is less effective Rattus norvegicus ?
-
 ?
1.3.1.22 progesterone + NADPH + H+
-
 Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
 ?
1.3.1.22 testosterone + NADPH + H+ very low activity Rattus norvegicus 5alpha-dihydrotestosterone + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH cannot be replaced by NADH Rattus norvegicus