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Literature summary extracted from

  • Bertics, P.J.; Karavolas, H.J.
    Partial characterization of the microsomal and solubilized hypothalamic progesterone 5alpha-reductase (1984), J. Steroid Biochem., 21, 305-314.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.22 iodoacetamide stimulatory on solubilized enzyme from microsomes Rattus norvegicus
1.3.1.22 N-ethylmaleimide stimulatory on solubilized enzyme from microsomes Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 4-Aza-4-methyl-5alpha-pregnane-3,20-dione
-
 Rattus norvegicus
1.3.1.22 Cu2+
-
 Rattus norvegicus
1.3.1.22 flavins and flavin analogs, high concentration Rattus norvegicus
1.3.1.22 p-chloromercuribenzoate complete inhibition Rattus norvegicus
1.3.1.22 Zn2+
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 0.000113
-
 progesterone
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.1.22 EDTA
-
 Rattus norvegicus
1.3.1.22 K+ stimulate Rattus norvegicus
1.3.1.22 Li+ stimulate Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.22 progesterone + NADPH + H+ Rattus norvegicus riboflavin-deficient diet decreases the enzyme activity, after 5 weeks no activity is remaining 5alpha-pregnan-3-20-dione + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 hypothalamus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 progesterone + NADPH + H+
-
 Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
 ?
1.3.1.22 progesterone + NADPH + H+ riboflavin-deficient diet decreases the enzyme activity, after 5 weeks no activity is remaining Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Rattus norvegicus