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Literature summary extracted from

  • Charbonneau, A.; The, V.L.
    Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme (2001), Biochim. Biophys. Acta, 1517, 228-235.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.3 expression in human HEK-293 cells Homo sapiens
1.3.1.3 pseudogene found Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.3 17alpha-hydroxyprogesterone + NADPH Homo sapiens
-
 ?
-
 ?
1.3.1.3 aldosterone + NADPH Homo sapiens low activity ?
-
 ?
1.3.1.3 corticosterone + NADPH + H+ Homo sapiens low activity ?
-
 ?
1.3.1.3 cortisol + NADPH Homo sapiens very low activity ?
-
 ?
1.3.1.3 progesterone + NADPH Homo sapiens
-
 ?
-
 ?
1.3.1.3 testosterone + NADPH + H+ Homo sapiens
-
 (5beta,17beta)-17-hydroxyandrostan-3-one + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.3 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.3 17alpha-hydroxyprogesterone + NADPH
-
 Homo sapiens ?
-
 ?
1.3.1.3 4-androstene-3,17-dione + NADPH
-
 Homo sapiens 5beta-androstan-3,17-dione + NADP+
-
 ?
1.3.1.3 aldosterone + NADPH low activity Homo sapiens ?
-
 ?
1.3.1.3 corticosterone + NADPH + H+ low activity Homo sapiens ?
-
 ?
1.3.1.3 cortisol + NADPH very low activity Homo sapiens ?
-
 ?
1.3.1.3 progesterone + NADPH
-
 Homo sapiens ?
-
 ?
1.3.1.3 testosterone + NADPH + H+
-
 Homo sapiens (5beta,17beta)-17-hydroxyandrostan-3-one + NADP+
-
 ?