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Literature summary extracted from
- Stereospecificity of the dihydroorotate-dehydrogenase reaction (1972), Eur. J. Biochem., 30, 130-137.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.14 | Faecalicatena orotica | - |
strain ATCC 13619 | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.3.1.14 | (S)-dihydroorotate + NAD+ = orotate + NADH + H+ | trans-dehydrogenation mechanism | Faecalicatena orotica |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.14 | additional information | - |
- |
Faecalicatena orotica |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.3.1.14 | -18°C, prepared enzyme, that is a yellow powder, several weeks, stable | Faecalicatena orotica |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.14 | (S)-dihydroorotate + NAD+ | anti-elimination of hydrogen from (S)-dihydroorotate | Faecalicatena orotica | orotate + NADH + H+ | - |
r |  |
| 1.3.1.14 | (S)-dihydroorotate + NAD+ | equilibrium favours direction of orotate reduction | Faecalicatena orotica | orotate + NADH + H+ | - |
r | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.14 | flavin | flavoprotein with two different flavins, probably FAD and FMN | Faecalicatena orotica | |
| 1.3.1.14 | flavin | flavin coenzyme | Faecalicatena orotica | |
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Release 2023.1 (January 2023)
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