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Literature summary extracted from

  • Shin, W.; Lindahl, P.A.
    Function and CO binding properties of the NiFe complex in carbon monoxide dehydrogenase from Clostridium thermoaceticum (1992), Biochemistry, 31, 12870-12875.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.7.4 1,10-phenanthroline 1 mM, inactivates CO/acetyl-CoA exchange activity completely but has no effect on CO oxidation Moorella thermoacetica
1.2.7.4 CO
-
 Moorella thermoacetica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.7.4 Iron the NiFe complex is required for catalyzing the exchange reaction and the acetyl-CoA synthase reaction Moorella thermoacetica
1.2.7.4 Nickel the NiFe complex is required for catalyzing the exchange reaction and the acetyl-CoA synthase reaction Moorella thermoacetica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.7.4 CO + H2O + electron acceptor Moorella thermoacetica delivery of a low-potential electron to the CO-bound NiFe complex is the physiological function of the CO oxidation reaction catalyzed by the enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.7.4 Moorella thermoacetica
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.7.4 0.32
-
 CO/acetyl-CoA exchange reaction Moorella thermoacetica
1.2.7.4 250
-
 CO oxidation Moorella thermoacetica

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.7.4 CO + H2O + electron acceptor delivery of a low-potential electron to the CO-bound NiFe complex is the physiological function of the CO oxidation reaction catalyzed by the enzyme Moorella thermoacetica ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.7.4 0.4
-
 CO noncompetitive inhibition of the acetyl-CoA exchange reaction Moorella thermoacetica