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Literature summary extracted from
- Increased hepatic retinal dehydrogenase activity after phenobarbital and ethanol administration (1989), Biochem. Pharmacol., 38, 97-103.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.36 | acetaldehyde | 0.2 mM, 0.5 mM and 1.0 mM, uncompetitive inhibition | Rattus norvegicus |  |
| 1.2.1.36 | Chloral hydrate | noncompetitive inhibition | Rattus norvegicus | |
| 1.2.1.36 | Disulfiram | 20 mM | Rattus norvegicus | |
| 1.2.1.36 | NaCN | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.36 | 0.066 | - |
retinal | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.2.1.36 | cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.36 | retinal + NAD+ + H2O | Rattus norvegicus | - |
retinoate + NADH | - |
? | |
| 1.2.1.36 | retinal + NAD+ + H2O | Rattus norvegicus BR | - |
retinoate + NADH | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.1.36 | Peromyscus maniculatus | - |
deermouse | - |
| 1.2.1.36 | Rattus norvegicus | - |
Sprague-Dawley, BR strain | - |
| 1.2.1.36 | Rattus norvegicus BR | - |
Sprague-Dawley, BR strain | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.2.1.36 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.36 | retinal + NAD+ + H2O | - |
Rattus norvegicus | retinoate + NADH | - |
? | |
| 1.2.1.36 | retinal + NAD+ + H2O | - |
Rattus norvegicus BR | retinoate + NADH | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.36 | NAD+ | - |
Rattus norvegicus | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.36 | 0.0126 | - |
Chloral hydrate | - |
Rattus norvegicus | |
| 1.2.1.36 | 0.53 | - |
acetaldehyde | standard deviation 0.01 mM | Rattus norvegicus | |
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