BRENDA - Enzyme Database show

Oxyanion specificity of L-Aspartate-beta-semialdehyde dehydrogenase

Kish, M.M.; Viola, R.E.; Inorg. Chem. 38, 818-820 (1999)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.11
Periodate
-
Escherichia coli
1.2.1.11
perrhenate
very weak inhibitor
Escherichia coli
1.2.1.11
phosphonate
weak inhibitor
Escherichia coli
1.2.1.11
tellurate
-
Escherichia coli
1.2.1.11
tungstate
-
Escherichia coli
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.2.1.11
0.14
-
vanadate
-
Escherichia coli
1.2.1.11
1.6
-
arsenate
-
Escherichia coli
1.2.1.11
2.9
-
phosphate
-
Escherichia coli
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.1.11
L-4-aspartyl phosphate + NADPH
Escherichia coli
-
L-aspartate 4-semialdehyde + phosphate + NADP+
-
Escherichia coli
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.2.1.11
Escherichia coli
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.11
L-4-aspartyl phosphate + NADPH
-
390200
Escherichia coli
L-aspartate 4-semialdehyde + phosphate + NADP+
-
390200
Escherichia coli
-
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
-
390200
Escherichia coli
L-4-aspartyl phosphate + NADPH
-
390200
Escherichia coli
r
1.2.1.11
additional information
the putative phosphate side contains arginine and a lysine that can provide electrostratic attraction to bind an oxyanion
390200
Escherichia coli
?
-
-
-
-
1.2.1.11
additional information
the kinetic parameters with arsenate are comparable to those of phosphate, vanadate is an excellent substrate for the enzyme
390200
Escherichia coli
?
-
-
-
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.2.1.11
NADP+
-
Escherichia coli
1.2.1.11
NADPH
-
Escherichia coli
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.2.1.11
0.22
-
Periodate
-
Escherichia coli
1.2.1.11
11
-
tellurate
-
Escherichia coli
1.2.1.11
17
-
phosphonate
-
Escherichia coli
1.2.1.11
26
-
tungstate
-
Escherichia coli
1.2.1.11
140
-
perrhenate
-
Escherichia coli
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.2.1.11
NADP+
-
Escherichia coli
1.2.1.11
NADPH
-
Escherichia coli
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.11
Periodate
-
Escherichia coli
1.2.1.11
perrhenate
very weak inhibitor
Escherichia coli
1.2.1.11
phosphonate
weak inhibitor
Escherichia coli
1.2.1.11
tellurate
-
Escherichia coli
1.2.1.11
tungstate
-
Escherichia coli
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.2.1.11
0.22
-
Periodate
-
Escherichia coli
1.2.1.11
11
-
tellurate
-
Escherichia coli
1.2.1.11
17
-
phosphonate
-
Escherichia coli
1.2.1.11
26
-
tungstate
-
Escherichia coli
1.2.1.11
140
-
perrhenate
-
Escherichia coli
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.2.1.11
0.14
-
vanadate
-
Escherichia coli
1.2.1.11
1.6
-
arsenate
-
Escherichia coli
1.2.1.11
2.9
-
phosphate
-
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.1.11
L-4-aspartyl phosphate + NADPH
Escherichia coli
-
L-aspartate 4-semialdehyde + phosphate + NADP+
-
Escherichia coli
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.11
L-4-aspartyl phosphate + NADPH
-
390200
Escherichia coli
L-aspartate 4-semialdehyde + phosphate + NADP+
-
390200
Escherichia coli
-
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
-
390200
Escherichia coli
L-4-aspartyl phosphate + NADPH
-
390200
Escherichia coli
r
1.2.1.11
additional information
the putative phosphate side contains arginine and a lysine that can provide electrostratic attraction to bind an oxyanion
390200
Escherichia coli
?
-
-
-
-
1.2.1.11
additional information
the kinetic parameters with arsenate are comparable to those of phosphate, vanadate is an excellent substrate for the enzyme
390200
Escherichia coli
?
-
-
-
-