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Literature summary extracted from

  • Bartlett, A.T.M.; White, P.J.
    Regulation of the enzymes of lysine biosynthesis in Bacillus sphaericus NCTC 9602 during vegetative growth (1986), J. Gen. Microbiol., 132, 3169-3177.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.11 L-lysine slightly represses the enzyme Lysinibacillus sphaericus
1.4.1.16 D-2,6-diaminopimelate
-
Lysinibacillus sphaericus
1.4.1.16 L-2,6-diaminopimelate
-
Lysinibacillus sphaericus
1.4.1.16 meso-diaminopimelate
-
Lysinibacillus sphaericus
1.17.1.8 1,10-phenanthroline
-
Lysinibacillus sphaericus
1.17.1.8 dipicolinate
-
Lysinibacillus sphaericus
1.17.1.8 additional information not inhibited by lysine, methionine and threonine Lysinibacillus sphaericus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NADPH Lysinibacillus sphaericus
-
meso-2,6-diaminoheptanedioate + H2O + NADP+
-
r
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H Lysinibacillus sphaericus highest activity during exponential growth phase 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
?
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H Lysinibacillus sphaericus repressed by lysine 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.11 Lysinibacillus sphaericus
-
-
-
1.4.1.16 Lysinibacillus sphaericus
-
-
-
1.17.1.8 Lysinibacillus sphaericus
-
NCTC 9602
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.17.1.8 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ partly repressed by lysine Lysinibacillus sphaericus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.11 0.04
-
assay system plus lysine or assays system plus lysine, threonine and methionine Lysinibacillus sphaericus
1.2.1.11 0.043
-
no addition to the assay system or assay system plus methionine Lysinibacillus sphaericus
1.2.1.11 0.048
-
assay system plus threonine Lysinibacillus sphaericus
1.4.1.16 0.03
-
reductive amination of 2-amino-6-oxopimelate in crude extracts at pH 7.5 in the presence of 1.67 mM meso-diaminopimelate Lysinibacillus sphaericus
1.4.1.16 0.25
-
reductive amination of 2-amino-6-oxopimelate in crude extracts at pH 7.5 Lysinibacillus sphaericus
1.4.1.16 0.45
-
oxidative deamination of meso-diaminopimelate in crude extracts at pH 10.5 Lysinibacillus sphaericus
1.17.1.8 0.029
-
during stationary phase Lysinibacillus sphaericus
1.17.1.8 0.04
-
during late exponential phase Lysinibacillus sphaericus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
Lysinibacillus sphaericus L-4-aspartyl phosphate + NADPH
-
?
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H
-
Lysinibacillus sphaericus meso-2,6-diaminoheptanedioate + H2O + NAD(P)+
-
r
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NADPH
-
Lysinibacillus sphaericus meso-2,6-diaminoheptanedioate + H2O + NADP+
-
r
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H
-
Lysinibacillus sphaericus 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
?
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H highest activity during exponential growth phase Lysinibacillus sphaericus 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
?
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H repressed by lysine Lysinibacillus sphaericus 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.1.8 30
-
assay at Lysinibacillus sphaericus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.1.8 7.2
-
-
Lysinibacillus sphaericus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.16 NADPH
-
Lysinibacillus sphaericus