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Literature summary extracted from

  • Cremer, J.; Treptow, C.; Eggeling, L.; Sahm, H.
    Regulation of enzymes of lysine biosynthesis in Corynebacterium glutamicum (1988), J. Gen. Microbiol., 134, 3221-3229.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.11 L-isoleucine inhibits, when added to a final concentration of 10 mM in the assay system produces a decrease of 0.003 units in specific activity Corynebacterium glutamicum
1.2.1.11 L-leucine inhibits, when added to a final concentration of 10 mM in the assay system produces a decrease of 0.004 units in specific activity Corynebacterium glutamicum
1.2.1.11 L-lysine enzyme assayed in the reverse reaction at pH 10 Corynebacterium glutamicum
1.2.1.11 L-methionine inhibits, when added to a final concentration of 10 mM in the assay system produces a decrease of 0.004 units in specific activity Corynebacterium glutamicum
1.2.1.11 L-threonine enzyme assayed in the reverse reaction at pH 10 Corynebacterium glutamicum
1.2.1.11 additional information
-
 Corynebacterium glutamicum

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.11 Corynebacterium glutamicum
-
-
-
1.4.1.16 Corynebacterium glutamicum
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.11 0.01
-
 grown in minimal medium or in minimal medium plus lysine, methionine and threonine Corynebacterium glutamicum
1.2.1.11 0.012
-
 grown in minimal medium plus isoleucine Corynebacterium glutamicum
1.2.1.11 0.013
-
 grown in minimal medium plus lysine or in minimal medium plus threonine Corynebacterium glutamicum
1.2.1.11 0.015
-
 grown in minimal medium plus leucine or in minimal medium plus methionine Corynebacterium glutamicum
1.2.1.11 0.02
-
 grown in complex medium Corynebacterium glutamicum
1.4.1.16 0.15
-
 activity in crude extracts of cells grown on complex medium Corynebacterium glutamicum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Corynebacterium glutamicum L-4-aspartyl phosphate + NADPH
-
 ?
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H
-
 Corynebacterium glutamicum meso-2,6-diaminoheptanedioate + H2O + NAD(P)+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.11 NADP+
-
 Corynebacterium glutamicum
1.4.1.16 NADPH
-
 Corynebacterium glutamicum