BRENDA - Enzyme Database show

Aspartic beta-semialdehyde dehydrogenase and aspartic beta-semialdehyde

Black, S.; Wright, N.G.; J. Biol. Chem. 213, 39-50 (1955)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.11
iodoacetate
inhibition of arsenolysis, inhibition of the reduction of beta-aspartyl phosphate
Saccharomyces cerevisiae
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.2.1.11
0.036
-
NADP+
-
Saccharomyces cerevisiae
1.2.1.11
0.083
-
NADPH
-
Saccharomyces cerevisiae
1.2.1.11
0.16
-
L-4-aspartyl phosphate
-
Saccharomyces cerevisiae
1.2.1.11
2.6
-
L-aspartate 4-semialdehyde
-
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.1.11
L-4-aspartyl phosphate + NADPH
Saccharomyces cerevisiae
-
L-aspartate 4-semialdehyde + phosphate + NADP+
-
Saccharomyces cerevisiae
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.2.1.11
Saccharomyces cerevisiae
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.2.1.11
using heat treatment, acid precipitation, protamine sulfate treatment and ammonium sulfate precipitation
Saccharomyces cerevisiae
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.2.1.11
additional information
-
-
Saccharomyces cerevisiae
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.11
L-4-aspartyl phosphate + NADPH
-
390188
Saccharomyces cerevisiae
L-aspartate 4-semialdehyde + phosphate + NADP+
-
390188
Saccharomyces cerevisiae
-
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
-
390188
Saccharomyces cerevisiae
L-4-aspartyl phosphate + NADPH
-
390188
Saccharomyces cerevisiae
r
1.2.1.11
additional information
when arsenate is substituted for phosphate the rates are about one-half those with corresponding phosphate concentrations
390188
Saccharomyces cerevisiae
?
-
-
-
-
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.2.1.11
8
9
L-aspartate 4-semialdehyde + arsenate
Saccharomyces cerevisiae
1.2.1.11
8
-
L-aspartyl phosphate + NADPH
Saccharomyces cerevisiae
1.2.1.11
9
-
L-aspartate 4-semialdehyde + PO43-
Saccharomyces cerevisiae
pH Range
EC Number
pH Minimum
pH Maximum
Commentary
Organism
1.2.1.11
8.4
9.5
at pH 8.4 and pH 9.5: 50% of maximal activity, L-aspartate 4-semialdehyde + phosphate
Saccharomyces cerevisiae
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.2.1.11
NADP+
-
Saccharomyces cerevisiae
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.2.1.11
NADP+
-
Saccharomyces cerevisiae
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.11
iodoacetate
inhibition of arsenolysis, inhibition of the reduction of beta-aspartyl phosphate
Saccharomyces cerevisiae
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.2.1.11
0.036
-
NADP+
-
Saccharomyces cerevisiae
1.2.1.11
0.083
-
NADPH
-
Saccharomyces cerevisiae
1.2.1.11
0.16
-
L-4-aspartyl phosphate
-
Saccharomyces cerevisiae
1.2.1.11
2.6
-
L-aspartate 4-semialdehyde
-
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.1.11
L-4-aspartyl phosphate + NADPH
Saccharomyces cerevisiae
-
L-aspartate 4-semialdehyde + phosphate + NADP+
-
Saccharomyces cerevisiae
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.2.1.11
using heat treatment, acid precipitation, protamine sulfate treatment and ammonium sulfate precipitation
Saccharomyces cerevisiae
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.2.1.11
additional information
-
-
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.11
L-4-aspartyl phosphate + NADPH
-
390188
Saccharomyces cerevisiae
L-aspartate 4-semialdehyde + phosphate + NADP+
-
390188
Saccharomyces cerevisiae
-
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
-
390188
Saccharomyces cerevisiae
L-4-aspartyl phosphate + NADPH
-
390188
Saccharomyces cerevisiae
r
1.2.1.11
additional information
when arsenate is substituted for phosphate the rates are about one-half those with corresponding phosphate concentrations
390188
Saccharomyces cerevisiae
?
-
-
-
-
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.2.1.11
8
9
L-aspartate 4-semialdehyde + arsenate
Saccharomyces cerevisiae
1.2.1.11
8
-
L-aspartyl phosphate + NADPH
Saccharomyces cerevisiae
1.2.1.11
9
-
L-aspartate 4-semialdehyde + PO43-
Saccharomyces cerevisiae
pH Range (protein specific)
EC Number
pH Minimum
pH Maximum
Commentary
Organism
1.2.1.11
8.4
9.5
at pH 8.4 and pH 9.5: 50% of maximal activity, L-aspartate 4-semialdehyde + phosphate
Saccharomyces cerevisiae