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Literature summary extracted from
- Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17alpha-hydroxylase and c17,20-lyase) associated with one protein (1981), Biochemistry, 20, 4037-4042.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.19 | 3-(6-Chloro-3-methyl-2-indenyl)pyridine | competitive inhibitor | Sus scrofa |  |
| 1.14.14.19 | 4-chloro-3,4-dihydro-2-(3-pyridyl)-1-(2H)-naphthalenone | competitive inhibitor | Sus scrofa | |
| 1.14.14.19 | CO | - |
Sus scrofa | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Sus scrofa | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.19 | Sus scrofa | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 1.14.14.19 | glycoprotein | three glucosamine residues per molecule | Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.19 | testis | neonatal | Sus scrofa | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Sus scrofa | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.19 | 37 | - |
- |
Sus scrofa |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.19 | 30 | 44 | hydroxylase and lyase activity decrease proportionally | Sus scrofa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.19 | 7.3 | - |
- |
Sus scrofa |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.19 | 0.00004 | - |
3-(6-Chloro-3-methyl-2-indenyl)pyridine | - |
Sus scrofa | |
| 1.14.14.19 | 0.0003 | - |
4-chloro-3,4-dihydro-2-(3-pyridyl)-1-(2H)-naphthalenone | - |
Sus scrofa | |
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