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Literature summary extracted from
- Studies on cytochrome P-450 (P-450 17alpha,lyase) from guinea pig adrenal microsomes. Dual function of a single enzyme and effect of cytochrome b5 (1985), Biochim. Biophys. Acta, 833, 151-160.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.19 | cytochrome b5 | above pH 6.3-6.5 stimulates 17alpha-hydrolase and c17,20-lyase activity | Cavia porcellus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.19 | cytochrome b5 | supresses 17alpha-hydrolase and C17,20-lyase activity below pH 6.3-6.5 | Cavia porcellus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.19 | microsome | - |
Cavia porcellus | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.19 | Cavia porcellus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.19 | adrenal gland | - |
Cavia porcellus | - |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.19 | 6.1 | - |
both 17alpha-hydroxylation and C17,20-lyase actiivty | Cavia porcellus |
| 1.14.14.19 | 6.6 | - |
C17,20-lyase activity after addition of cytochrome b5 | Cavia porcellus |
| 1.14.14.19 | 7 | - |
17alpha-hydroxylation after addition of cytochrome b5 | Cavia porcellus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.19 | NADPH | - |
Cavia porcellus |  |
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