EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.19 | 22-Amino-23,24-bisnor-5-cholen-3beta-ol | type II competitive inhibitor | Bos taurus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.14.19 | microsome | endoplasmic reticulum | Bos taurus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.19 | Fe3+ | heme | Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.19 | pregnenolone + AH2 + O2 | Bos taurus | - |
17alpha-hydroxypregnenolone + A + H2O | - |
? | |
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Bos taurus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.19 | Bos taurus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.19 | adrenal gland | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.19 | pregnenolone + AH2 + O2 | - |
Bos taurus | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Bos taurus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.14.19 | 25 | - |
assay at | Bos taurus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.14.14.19 | 7.4 | - |
assay at | Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.19 | NADPH | - |
Bos taurus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.14.19 | 0.000029 | - |
22-Amino-23,24-bisnor-5-cholen-3beta-ol | 17alpha-hydroxylase activity | Bos taurus |