Literature summary extracted from

Angelastro, M.R.; Laughlin, M.E.; Schatzman, G.L.; Bey, P.; Blohm, T.R.
17beta-(Cyclopropylamino)-androst-5-en-3 beta-ol, a selective mechanism-based inhibitor of cytochrome P450(17alpha) (steroid 17alpha-hydroxylase/C17-20 lyase) (1989), Biochem. Biophys. Res. Commun., 162, 1571-1577.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.14.19	17beta-(cyclopropylamino)-androst-5-en-3beta-ol	mechanism-based inhibitor, irreversible inhibition	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.14.14.19	microsome	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.14.19	pregnenolone + AH2 + O2	Homo sapiens	-	17alpha-hydroxypregnenolone + A + H2O	product eliminates at C20,21 acetate to yield dehydroepiandrosterone	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.19	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.14.19	testis	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.19	pregnenolone + AH2 + O2	-	Homo sapiens	17alpha-hydroxypregnenolone + A + H2O	product eliminates at C20,21 acetate to yield dehydroepiandrosterone	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.14.19	NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)