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Literature summary extracted from

  • Haidar, S.; Klein, C.D.; Hartmann, R.W.
    Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of P450 17 (1 alpha-hydroxylase/C17-20-lyase) (2001), Arch. Pharm., 334, 138-140.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.19 3beta-hydroxy-23,24-bisnor-5-cholenic-hydroxamic acid at 0.0025 mM 20% inhibition Homo sapiens
1.14.14.19 3beta-hydroxy-23,24-bisnor-5-cholenic-hydroxamic acid at 0.125 mM 19% inhibition Rattus norvegicus
1.14.14.19 3beta-hydroxy-5-androsten-17beta-hydroxamic acid at 0.0025 mM 17% inhibition Homo sapiens
1.14.14.19 3beta-hydroxy-5-androsten-17beta-hydroxamic acid at 0.125 mM 18% inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.19 microsome
-
 Homo sapiens
-
-
1.14.14.19 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O product eliminates at C20,21 acetate to yield androstenedione ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus
-
 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O product eliminates at C20,21 acetate to yield androstenedione ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Homo sapiens
-
-
-
1.14.14.19 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.19 testis
-
 Homo sapiens
-
1.14.14.19 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O product eliminates at C20,21 acetate to yield androstenedione ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O product eliminates at C20,21 acetate to yield androstenedione ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.19 P450 17
-
 Homo sapiens
1.14.14.19 P450 17
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.14.19 32
-
-
 Rattus norvegicus
1.14.14.19 37
-
-
 Homo sapiens
1.14.14.19 37
-
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.19 NADPH
-
 Homo sapiens
1.14.14.19 NADPH
-
 Rattus norvegicus