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Literature summary extracted from

  • Morgan, L.R.; Weimorts, D.M.; Aubert, C.C.
    Oxidation of 3-hydroxyanthranilic acid by a soluble liver fraction from poikilothermic vertebrates (1965), Biochim. Biophys. Acta, 100, 393-402.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.3.5 alpha,alpha'-dipyridyl
-
 Rattus norvegicus
1.10.3.5 CN-
-
 Rattus norvegicus
1.10.3.5 Dopa
-
 Rattus norvegicus
1.10.3.5 EDTA
-
 Rattus norvegicus
1.10.3.5 Fe2+
-
 Rattus norvegicus
1.10.3.5 N3-
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2 Rattus norvegicus
-
 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.5 Alligator mississippiensis
-
 american alligator
-
1.10.3.5 Amphiuma means
-
 salamander, two-toad amphiuma
-
1.10.3.5 Chelydra serpentina
-
 snapping turtle
-
1.10.3.5 Felis catus
-
 cat
-
1.10.3.5 Pseudemys concinna floridana
-
 turtle, red-eared slider
-
1.10.3.5 Rattus norvegicus
-
-
-
1.10.3.5 Rhinella marina
-
 cane toad
-
1.10.3.5 Streptomyces antibioticus
-
-
-
1.10.3.5 Terrapene carolina
-
 eastern box turtle
-
1.10.3.5 Trachemys scripta
-
 turtle, florida cooter
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.10.3.5
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.10.3.5 liver
-
 Rattus norvegicus
-
1.10.3.5 liver
-
 Felis catus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.10.3.5 1.141
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.10.3.5 -20°C, can be stored for several months with no detectable inactivation Rattus norvegicus
1.10.3.5 20°C, shows little loss of activity at room temperature Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Rattus norvegicus 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Felis catus 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Rhinella marina 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Streptomyces antibioticus 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Trachemys scripta 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Alligator mississippiensis 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Amphiuma means 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Chelydra serpentina 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Pseudemys concinna floridana 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 2 3-hydroxyanthranilic acid + 2 O2
-
 Terrapene carolina 2-amino-2H-phenoxazin-3-one-1,9-dicarboxylic acid + 2 H2O2
-
 ?
1.10.3.5 3-hydroxy-4-methylanthranilic acid + O2
-
 Rattus norvegicus actinocin
-
 ?
1.10.3.5 3-hydroxy-4-methylanthranilic acid + O2
-
 Streptomyces antibioticus actinocin
-
 ?
1.10.3.5 3-hydroxy-L-kynurenine + O2
-
 Rattus norvegicus (2S)-2-amino-4-(6-imino-5-oxocyclohexa-1,3-dien-1yl)-4-oxo-butanoic acid + H2O2
-
 ?
1.10.3.5 ethyl-3-hydroxyanthranilate + O2
-
 Rattus norvegicus ?
-
 ?
1.10.3.5 additional information 2-amino-3-hydroxytoluene is no substrate Rattus norvegicus ?
-
 ?
1.10.3.5 o-aminophenol + O2
-
 Rattus norvegicus phenoxazinone + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.10.3.5 o-aminophenol:O2 oxidoreductase
-
 Streptomyces antibioticus
1.10.3.5 phenoxazine-synthetase
-
 Streptomyces antibioticus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.10.3.5 7.2 7.4
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.10.3.5 6.5 8.5
-
 Rattus norvegicus