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Literature summary extracted from

  • Karavolas, H.J.; Hodges, D.R.
    Changes in pituitary, hypothalamic and brain progestin-metabolizing enzyme activities during lactation (1993), J. Steroid Biochem. Mol. Biol., 44, 299-303.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.50 cytoplasmic membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
-
-
1.1.1.50 cytosol NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus 5829
-
1.3.1.22 cytoplasmic membrane
-
 Rattus norvegicus
-
-
1.3.1.22 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H + H+ Rattus norvegicus 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
 r
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H + H+ Rattus norvegicus activity higher during lactation in female rats 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
 r
1.1.1.50 5alpha-pregnan-3,20-dione + NADPH Rattus norvegicus
-
 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
 r
1.3.1.22 progesterone + NADPH + H+ Rattus norvegicus activity is higher in hypothalamus of non-lactating female rats than in lactating 5alpha-pregnan-3-20-dione + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.50 Rattus norvegicus
-
 NADPH- and NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity
-
1.3.1.22 Rattus norvegicus
-
 female rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.50 brain distribution in brain regions of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
-
1.1.1.50 brain NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity is decreased by 40-50% in lactating rats Rattus norvegicus
-
1.1.1.50 hypophysis anterior Rattus norvegicus
-
1.1.1.50 hypophysis cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, increase of both enzymes during lactation Rattus norvegicus
-
1.1.1.50 hypothalamus cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
-
1.3.1.22 brain
-
 Rattus norvegicus
-
1.3.1.22 hypophysis anterior Rattus norvegicus
-
1.3.1.22 hypothalamus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H
-
 Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+
-
 ?
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H + H+ 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin Rattus norvegicus 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
 r
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H + H+ activity higher during lactation in female rats Rattus norvegicus 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
 r
1.1.1.50 5alpha-pregnan-3,20-dione + NADPH
-
 Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
 ?
1.1.1.50 5alpha-pregnan-3,20-dione + NADPH
-
 Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
 r
1.3.1.22 progesterone + NADPH + H+
-
 Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
 r
1.3.1.22 progesterone + NADPH + H+ activity is higher in hypothalamus of non-lactating female rats than in lactating Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.50 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase NADH- and NADPH-linked Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.50 NADH plasma membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
1.1.1.50 NADPH cytosolic NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
1.3.1.22 NADPH
-
 Rattus norvegicus