EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.50 | cytoplasmic membrane | integral membrane protein | Rattus norvegicus | - |
- |
1.1.1.50 | cytoplasmic membrane | NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus | - |
- |
1.1.1.50 | cytosol | NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus | 5829 | - |
1.3.1.22 | cytoplasmic membrane | - |
Rattus norvegicus | - |
- |
1.3.1.22 | cytosol | - |
Rattus norvegicus | 5829 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.50 | 5alpha-dihydrotestosterone + NAD(P)H + H+ | Rattus norvegicus | NADH-linked, particulate enzyme prefers oxidative reaction, while the NADPH-linked, cytosolic enzyme prefers the reductive reaction | 5alpha-androstane-3alpha,17beta-diol + NAD(P)+ | - |
r | |
1.1.1.50 | 5alpha-pregnan-3,20-dione + NAD(P)H + H+ | Rattus norvegicus | 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin | 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+ | - |
r | |
1.1.1.50 | 5alpha-pregnan-3,20-dione + NADPH | Rattus norvegicus | - |
3alpha-hydroxy-5alpha-pregnan-20-one + NADP+ | - |
r | |
1.3.1.22 | progesterone + NADPH + H+ | Rattus norvegicus | - |
5alpha-pregnan-3-20-dione + NADP+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.50 | Rattus norvegicus | - |
NADPH- and NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | - |
1.3.1.22 | Rattus norvegicus | - |
female rat | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.50 | brain | distribution in brain regions of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus | - |
1.3.1.22 | brain | distribution in brain areas | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.50 | 5alpha-dihydrotestosterone + NAD(P)H + H+ | NADH-linked, particulate enzyme prefers oxidative reaction, while the NADPH-linked, cytosolic enzyme prefers the reductive reaction | Rattus norvegicus | 5alpha-androstane-3alpha,17beta-diol + NAD(P)+ | - |
r | |
1.1.1.50 | 5alpha-pregnan-3,20-dione + NAD(P)H | 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin | Rattus norvegicus | 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
? | |
1.1.1.50 | 5alpha-pregnan-3,20-dione + NAD(P)H + H+ | 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin | Rattus norvegicus | 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+ | - |
r | |
1.1.1.50 | 5alpha-pregnan-3,20-dione + NADPH | - |
Rattus norvegicus | 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+ | - |
? | |
1.1.1.50 | 5alpha-pregnan-3,20-dione + NADPH | - |
Rattus norvegicus | 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+ | - |
r | |
1.1.1.50 | 5beta-dihydrotestosterone + NAD(P)H | NADH-linked, particulate enzyme prefers oxidative reaction, while the NADPH-linked, cytosolic enzyme prefers the reductive reaction | Rattus norvegicus | 5beta-androstan-3alpha,17beta-diol + NAD(P)+ | - |
r | |
1.3.1.22 | progesterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-pregnan-3-20-dione + NADP+ | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.50 | 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.50 | NADH | plasma membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus | |
1.1.1.50 | NADPH | cytosolic NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity | Rattus norvegicus | |
1.3.1.22 | NADPH | - |
Rattus norvegicus |