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Literature summary extracted from

  • Li, X.; Bertics, P.J.; Karavolas, H.J.
    Regional distribution of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductases in female rat brain (1997), J. Steroid Biochem. Mol. Biol., 60, 311-318.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.50 cytoplasmic membrane integral membrane protein Rattus norvegicus
-
-
1.1.1.50 cytoplasmic membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
-
-
1.1.1.50 cytosol NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus 5829
-
1.3.1.22 cytoplasmic membrane
-
Rattus norvegicus
-
-
1.3.1.22 cytosol
-
Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.50 5alpha-dihydrotestosterone + NAD(P)H + H+ Rattus norvegicus NADH-linked, particulate enzyme prefers oxidative reaction, while the NADPH-linked, cytosolic enzyme prefers the reductive reaction 5alpha-androstane-3alpha,17beta-diol + NAD(P)+
-
r
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H + H+ Rattus norvegicus 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
r
1.1.1.50 5alpha-pregnan-3,20-dione + NADPH Rattus norvegicus
-
3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
r
1.3.1.22 progesterone + NADPH + H+ Rattus norvegicus
-
5alpha-pregnan-3-20-dione + NADP+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.50 Rattus norvegicus
-
NADPH- and NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity
-
1.3.1.22 Rattus norvegicus
-
female rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.50 brain distribution in brain regions of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
-
1.3.1.22 brain distribution in brain areas Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.50 5alpha-dihydrotestosterone + NAD(P)H + H+ NADH-linked, particulate enzyme prefers oxidative reaction, while the NADPH-linked, cytosolic enzyme prefers the reductive reaction Rattus norvegicus 5alpha-androstane-3alpha,17beta-diol + NAD(P)+
-
r
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+
-
?
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H + H+ 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin Rattus norvegicus 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
r
1.1.1.50 5alpha-pregnan-3,20-dione + NADPH
-
Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
?
1.1.1.50 5alpha-pregnan-3,20-dione + NADPH
-
Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
r
1.1.1.50 5beta-dihydrotestosterone + NAD(P)H NADH-linked, particulate enzyme prefers oxidative reaction, while the NADPH-linked, cytosolic enzyme prefers the reductive reaction Rattus norvegicus 5beta-androstan-3alpha,17beta-diol + NAD(P)+
-
r
1.3.1.22 progesterone + NADPH + H+
-
Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.50 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.50 NADH plasma membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
1.1.1.50 NADPH cytosolic NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
1.3.1.22 NADPH
-
Rattus norvegicus