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Literature summary extracted from

  • Kruger, S.; Schlegel, W.
    Prostaglandin-E2 9-ketoreductase from human uterine decidua vera (1986), Eur. J. Biochem., 157, 481-485.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.189 Ca2+
-
 Homo sapiens
1.1.1.189 Oxytocin
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.189 17beta-estradiol
-
 Homo sapiens
1.1.1.189 cortisol
-
 Homo sapiens
1.1.1.189 Fentiazac non competitive Homo sapiens
1.1.1.189 indomethacin non competitive Homo sapiens
1.1.1.189 progesterone non competitive Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.189 0.0016
-
 NADPH
-
 Homo sapiens
1.1.1.189 0.092
-
 prostaglandin E2
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.189 29000
-
 gel filtration Homo sapiens
1.1.1.189 31000
-
 alpha, 1 * 31000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.189 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ Homo sapiens might be an important factor in the cascade of events leading to uterine contractions and parturition (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.189 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.189 decidua parietalis uterine Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.189 0.00052
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.189 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
 Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
 ?
1.1.1.189 (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ might be an important factor in the cascade of events leading to uterine contractions and parturition Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.189 monomer alpha, 1 * 31000, SDS-PAGE Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.189 NADPH
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.189 0.45
-
 Fentiazac non competitive Homo sapiens
1.1.1.189 0.85
-
 indomethacin non competitive Homo sapiens
1.1.1.189 1.5
-
 progesterone non competitive Homo sapiens