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Literature summary extracted from

  • Spona, J.
    Differences in inhibition by various steroids of rat testis and Pseudomonas testosteroni DELTA5-3beta-hydroxysteroid dehydrogenase (1983), Endocrinol. Exp., 17, 107-118.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.145 ethynylestradiol
-
 Comamonas testosteroni
1.1.1.145 ethynylestradiol
-
 Rattus norvegicus
1.1.1.145 Norethisterone
-
 Comamonas testosteroni
1.1.1.145 Norethisterone
-
 Rattus norvegicus
1.1.1.145 Norethisterone acetate
-
 Comamonas testosteroni
1.1.1.145 Norethisterone acetate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.145 0.005
-
 dehydroepiandrosterone
-
 Rattus norvegicus
1.1.1.145 0.01
-
 dehydroepiandrosterone
-
 Comamonas testosteroni

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.145 microsome
-
 Rattus norvegicus
-
-
1.1.1.145 microsome
-
 Comamonas testosteroni
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 dehydroepiandrosterone + NAD+ Rattus norvegicus
-
 androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 dehydroepiandrosterone + NAD+ Comamonas testosteroni
-
 androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD(P)+ Rattus norvegicus
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?
1.1.1.145 pregnenolone + NAD(P)+ Comamonas testosteroni
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Comamonas testosteroni
-
-
-
1.1.1.145 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
 Rattus norvegicus 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
 ?
1.1.1.145 3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
 Comamonas testosteroni 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
 ?
1.1.1.145 dehydroepiandrosterone + NAD+
-
 Rattus norvegicus androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 dehydroepiandrosterone + NAD+
-
 Comamonas testosteroni androst-5-en-3,17-dione + NADH + H+
-
 ?
1.1.1.145 pregnenolone + NAD(P)+
-
 Rattus norvegicus pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?
1.1.1.145 pregnenolone + NAD(P)+
-
 Comamonas testosteroni pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
 Rattus norvegicus
1.1.1.145 NAD+
-
 Comamonas testosteroni