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Literature summary extracted from

  • Armstrong, D.G.
    Properties of 5-ene-3beta-hydroxysteroid dehydrogenase in granulosa tissue from the domestic fowl (Gallus domesticus) (1982), J. Steroid Biochem., 17, 225-230.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.145 20alpha-hydroxy-4-pregnen-3-one
-
 Gallus gallus
1.1.1.145 20beta-hydroxy-4-pregnen-3-one
-
 Gallus gallus
1.1.1.145 androstenedione
-
 Gallus gallus
1.1.1.145 estradiol-17beta
-
 Gallus gallus
1.1.1.145 progesterone
-
 Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.145 additional information
-
 additional information
-
 Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.145 microsome
-
 Gallus gallus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 pregnenolone + NAD(P)+ Gallus gallus
-
 pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Gallus gallus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 granulosa cell preovulatory follicular Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
 Gallus gallus 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
 ?
1.1.1.145 pregnenolone + NAD(P)+
-
 Gallus gallus pregn-5-en-3,20-dione + NAD(P)H + H+
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.145 55
-
 50 min, in microsomes 40-55% loss of activity, solubilized 80% loss of activity Gallus gallus
1.1.1.145 60
-
 microsomal fraction, inactivation Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
 Gallus gallus