Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Douc-Rasy, S.; Kayser, A.; Riou, J.F.; Riou, G.
    ATP-independent type II topoisomerase from trypanosomes (1986), Proc. Natl. Acad. Sci. USA, 83, 7152-7156.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 Berenil
-
 Trypanosoma cruzi
5.6.2.2 Clorobiocin
-
 Trypanosoma cruzi
5.6.2.2 coumermycin coumermycin A2 Trypanosoma cruzi
5.6.2.2 ellipticines
-
 Trypanosoma cruzi
5.6.2.2 Hydroxystilbamidine
-
 Trypanosoma cruzi
5.6.2.2 KCl above 50 mM Trypanosoma cruzi
5.6.2.2 NaCl above 50 mM Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.2.2 Ca2+ can substitute for Mg2+ Trypanosoma cruzi
5.6.2.2 K+ required Trypanosoma cruzi
5.6.2.2 Mg2+ required Trypanosoma cruzi
5.6.2.2 Mn2+ can substitute for Mg2+ Trypanosoma cruzi

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.6.2.2 200000
-
 sedimentation equilibrium centrifugation Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Trypanosoma cruzi
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.6.2.2 additional information
-
-
 Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 additional information the enzyme can alter the linking number of DNA only in steps of two Trypanosoma cruzi ?
-
 ?
5.6.2.2 additional information unknotting activity Trypanosoma cruzi ?
-
 ?
5.6.2.2 additional information no ATPase activity Trypanosoma cruzi ?
-
 ?
5.6.2.2 network of DNA rings + ATP + H2O decatenation Trypanosoma cruzi monomeric DNA circles + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O catenation Trypanosoma cruzi catenated DNA networks + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O catenation in absence of ATP Trypanosoma cruzi catenated DNA networks + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O relaxation Trypanosoma cruzi relaxed DNA + ADP + phosphate
-
 ?