EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.1 | additional information | enzyme is posttranslationally modified and presumably regulated by phosphorylation | eukaryota |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
5.6.2.2 | determination of crystal structure of fragments | eukaryota |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.1 | camptothecins | - |
eukaryota | |
5.6.2.1 | camptothecins | - |
Vaccinia virus | |
5.6.2.1 | topotecan | - |
eukaryota | |
5.6.2.2 | 2-Nitroimidazoles | - |
eukaryota | |
5.6.2.2 | 9-Hydroxy-isoellipticine | - |
eukaryota | |
5.6.2.2 | Aclarubicin | - |
eukaryota | |
5.6.2.2 | Acridines | - |
eukaryota | |
5.6.2.2 | adriamycin | - |
eukaryota | |
5.6.2.2 | Epipodophyllotoxins | - |
eukaryota | |
5.6.2.2 | genistein | - |
eukaryota | |
5.6.2.2 | Merbarone | - |
eukaryota | |
5.6.2.2 | Mitoxantrone | - |
eukaryota | |
5.6.2.2 | quinolones | - |
eukaryota | |
5.6.2.2 | suramin | - |
eukaryota |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.1 | Mg2+ | no requirement for Mg2+ | eukaryota | |
5.6.2.1 | Mg2+ | no requirement for Mg2+ | Vaccinia virus | |
5.6.2.1 | Mg2+ | no requirement for Mg2+ | Rabbit fibroma virus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.6.2.1 | additional information | eukaryota | enzyme controls the topological state of DNA | ? | - |
? | |
5.6.2.1 | additional information | Vaccinia virus | enzyme controls the topological state of DNA | ? | - |
? | |
5.6.2.1 | additional information | Rabbit fibroma virus | enzyme controls the topological state of DNA | ? | - |
? | |
5.6.2.1 | additional information | eukaryota | plays a role in transcriptional elongation | ? | - |
? | |
5.6.2.1 | additional information | eukaryota | plays a crucial role in controlling the physiological functions of DNA | ? | - |
? | |
5.6.2.1 | additional information | eukaryota | plays a direct role in the regulation of transcriptional initiation by acting as a repressor of the basal-level transcription | ? | - |
? | |
5.6.2.2 | additional information | eukaryota | involvement in RNA polymerase II transcription | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.6.2.1 | eukaryota | - |
- |
- |
5.6.2.1 | Rabbit fibroma virus | - |
- |
- |
5.6.2.1 | Vaccinia virus | - |
- |
- |
5.6.2.2 | Bacteria | - |
- |
- |
5.6.2.2 | eukaryota | - |
- |
- |
5.6.2.2 | Homo sapiens | - |
- |
- |
5.6.2.2 | Mus musculus | - |
- |
- |
5.6.2.2 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
5.6.2.1 | ATP-independent breakage of single-stranded DNA, followed by passage and rejoining | acts by directing a nucleophilic attack from the hydroxyl group of an internal Tyr into a phosphodiester bond in the DNA backbone, resulting in nicking of one strand of the DNA double helix and formation of a covalent linkage between the 3'-phosphate and the Tyr hydroxyl group | eukaryota | |
5.6.2.2 | ATP-dependent breakage, passage and rejoining of double-stranded DNA | mechanistic studies | eukaryota |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.6.2.1 | additional information | enzyme controls the topological state of DNA | eukaryota | ? | - |
? | |
5.6.2.1 | additional information | enzyme controls the topological state of DNA | Vaccinia virus | ? | - |
? | |
5.6.2.1 | additional information | enzyme controls the topological state of DNA | Rabbit fibroma virus | ? | - |
? | |
5.6.2.1 | additional information | plays a role in transcriptional elongation | eukaryota | ? | - |
? | |
5.6.2.1 | additional information | plays a crucial role in controlling the physiological functions of DNA | eukaryota | ? | - |
? | |
5.6.2.1 | additional information | plays a direct role in the regulation of transcriptional initiation by acting as a repressor of the basal-level transcription | eukaryota | ? | - |
? | |
5.6.2.1 | supercoiled DNA | rather weak sequence specificity | eukaryota | relaxed closed circular DNA | - |
? | |
5.6.2.1 | supercoiled DNA | rather weak sequence specificity | Vaccinia virus | relaxed closed circular DNA | - |
? | |
5.6.2.1 | supercoiled DNA | rather weak sequence specificity | Rabbit fibroma virus | relaxed closed circular DNA | - |
? | |
5.6.2.1 | supercoiled DNA | when oligonucleotide DNA duplexes are used as substrates, the generated cleavage complex contains an active enzyme, which is able to ligate the cleaved DNA to a variety of DNA fragments containing a free 5'-OH end | Vaccinia virus | relaxed closed circular DNA | - |
? | |
5.6.2.1 | supercoiled DNA | single-strand of DNA double helix | eukaryota | relaxed closed circular DNA | - |
? | |
5.6.2.1 | supercoiled DNA | single-strand of DNA double helix | Vaccinia virus | relaxed closed circular DNA | - |
? | |
5.6.2.1 | supercoiled DNA | single-strand of DNA double helix | Rabbit fibroma virus | relaxed closed circular DNA | - |
? | |
5.6.2.1 | supercoiled DNA | relaxation | eukaryota | relaxed closed circular DNA | - |
? | |
5.6.2.1 | supercoiled DNA | relaxation | Vaccinia virus | relaxed closed circular DNA | - |
? | |
5.6.2.1 | supercoiled DNA | relaxation | Rabbit fibroma virus | relaxed closed circular DNA | - |
? | |
5.6.2.2 | additional information | involvement in RNA polymerase II transcription | eukaryota | ? | - |
? | |
5.6.2.2 | network of DNA rings + ATP + H2O | decatenation | Bacteria | monomeric DNA circles + ADP + phosphate | - |
? | |
5.6.2.2 | network of DNA rings + ATP + H2O | decatenation | eukaryota | monomeric DNA circles + ADP + phosphate | - |
? | |
5.6.2.2 | network of DNA rings + ATP + H2O | decatenation | Mus musculus | monomeric DNA circles + ADP + phosphate | - |
? | |
5.6.2.2 | network of DNA rings + ATP + H2O | decatenation | Homo sapiens | monomeric DNA circles + ADP + phosphate | - |
? | |
5.6.2.2 | network of DNA rings + ATP + H2O | decatenation | Saccharomyces cerevisiae | monomeric DNA circles + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | catenation | Bacteria | catenated DNA networks + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | catenation | eukaryota | catenated DNA networks + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | catenation | Mus musculus | catenated DNA networks + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | catenation | Homo sapiens | catenated DNA networks + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | catenation | Saccharomyces cerevisiae | catenated DNA networks + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | relaxation | Bacteria | relaxed DNA + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | relaxation | eukaryota | relaxed DNA + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | relaxation | Mus musculus | relaxed DNA + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | relaxation | Homo sapiens | relaxed DNA + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | relaxation | Saccharomyces cerevisiae | relaxed DNA + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | relaxation of negatively or positively supercoiled DNA | Bacteria | relaxed DNA + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | relaxation of negatively or positively supercoiled DNA | eukaryota | relaxed DNA + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | relaxation of negatively or positively supercoiled DNA | Saccharomyces cerevisiae | relaxed DNA + ADP + phosphate | - |
? |