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Literature summary extracted from

  • Duguet, M.; Lavenot, C.; Harper, F.; Mirambeau, G.; De Recondo, A.M.
    DNA topoisomerases from rat liver: physiological variations (1983), Nucleic Acids Res., 11, 1059-1075.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.2.1 nucleus
-
 Rattus norvegicus 5634
-
5.6.2.2 nucleus
-
 Cricetulus griseus 5634
-
5.6.2.2 nucleus
-
 Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.2.2 additional information Rattus norvegicus possible involvement in DNA replication ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.1 Rattus norvegicus
-
-
-
5.6.2.2 Cricetulus griseus
-
-
-
5.6.2.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.1 liver topoisomerase I activity is not significantly changed as a function of regeneration time after partial hepatectomy Rattus norvegicus
-
5.6.2.2 liver activity is considerably increased as a function of regeneration time after partial hepatectomy Rattus norvegicus
-
5.6.2.2 ovary cell line wild type and epipodophyllotoxin-resistant line VpmR-5 Cricetulus griseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.1 Nicked circular DNA pBR322 DNA Rattus norvegicus Large catenated DNA networks
-
 ?
5.6.2.1 Nicked circular DNA catenation reaction Rattus norvegicus Large catenated DNA networks
-
 ?
5.6.2.1 supercoiled DNA relaxation Rattus norvegicus relaxed closed circular DNA
-
 ?
5.6.2.2 additional information possible involvement in DNA replication Rattus norvegicus ?
-
 ?
5.6.2.2 network of DNA rings + ATP + H2O decatenation Cricetulus griseus monomeric DNA circles + ADP + phosphate
-
 ?
5.6.2.2 network of DNA rings + ATP + H2O decatenation Rattus norvegicus monomeric DNA circles + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O catenation Cricetulus griseus catenated DNA networks + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O catenation Rattus norvegicus catenated DNA networks + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O relaxation Cricetulus griseus relaxed DNA + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O relaxation Rattus norvegicus relaxed DNA + ADP + phosphate
-
 ?