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Literature summary extracted from

  • Ivanov, V.A.; Melnikov, A.A.; Terpilovska, O.N.
    DNA topoisomerase I from rat brain neurons (1986), Biochim. Biophys. Acta, 866, 154-160.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.1 poly(dG) not by other homopolymerical deoxyribonucleotides Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.2.1 K+ stimulates, optimal concentration: 175-200 mM. K+ stimulates 10-15% more effectively than Na+ Rattus norvegicus
5.6.2.1 Na+ stimulates, optimal concentration: 175-200 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.2.1
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.1 cerebral cortex neuron Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.6.2.1 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.1 supercoiled DNA relaxation Rattus norvegicus relaxed closed circular DNA
-
 ?
5.6.2.1 supercoiled DNA enzyme links to the 3' ends of the broken DNA strands Rattus norvegicus relaxed closed circular DNA
-
 ?

Subunits

EC Number Subunits Comment Organism
5.6.2.1 ? proteins with MW 75000, 83000, 91000 or 100000 with DNA topoisomerase I activity are detected Rattus norvegicus