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Literature summary extracted from

  • Trumble, G.E.; Smith, M.A.; Winder, W.W.
    Purification and characterization of rat skeletal muscle acetyl-CoA carboxylase (1995), Eur. J. Biochem., 231, 192-198.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 malonyl-CoA
-
 Rattus norvegicus
6.4.1.2 palmitoyl-CoA
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.4.1.2 0.0215
-
 acetyl-CoA adipose tissue Rattus norvegicus
6.4.1.2 0.0317
-
 acetyl-CoA hindlimb muscle Rattus norvegicus
6.4.1.2 0.0576
-
 ATP hindlimb muscle Rattus norvegicus
6.4.1.2 0.1065
-
 ATP adipose tissue Rattus norvegicus
6.4.1.2 2.25
-
 HCO3-
-
 Rattus norvegicus
6.4.1.2 2.73
-
 HCO3- adipose tissue Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.4.1.2 265000
-
 x * 265000, adipose tissue, SDS-PAGE Rattus norvegicus
6.4.1.2 265000
-
 x * 265000, and a minor band at 280000 MW, liver, SDS-PAGE Rattus norvegicus
6.4.1.2 272000
-
 x * 272000, and a minor band at 265000 MW, hindlimb muscle, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.4.1.2 hindlimb muscle Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.2 liver
-
 Rattus norvegicus
-
6.4.1.2 muscle hindlimb Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.2 2.6
-
 hindlimb muscle Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
6.4.1.2 -70°C, stable for up to 8 months Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
6.4.1.2 ? x * 272000, and a minor band at 265000 MW, hindlimb muscle, SDS-PAGE Rattus norvegicus
6.4.1.2 ? x * 265000, adipose tissue, SDS-PAGE Rattus norvegicus
6.4.1.2 ? x * 265000, and a minor band at 280000 MW, liver, SDS-PAGE Rattus norvegicus