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Literature summary extracted from

  • Moule, S.K.; Edgell, N.J.; Borthwick, A.C.; Denton, R.M.
    Coenzyme A is a potent inhibitor of acetyl-CoA carboxylase from rat epididymal fat-pads (1992), Biochem. J., 283, 35-38.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 CoA inhibition requires the presence of MgATP2-, but is independent of phosphorylation of the enzyme, the effect is complete in about 5 min and is associated with depolymerization of acetyl-CoA carboxylase, half-maximal inhibition at 0.04 mM CoA, inhibition is partially reversed by incubation with citrate and more fully overcome by treatment of the enzyme with the insulin-stimulated acetyl-CoA carboxylase Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.2 fat pad epididymal Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?