BRENDA - Enzyme Database show

Nitric oxide modulates the activity of the hemoproteins prostaglandin I2 synthase and thromboxane A2 synthase

Wade, M.L.; Fitzpatrick, F.A.; Arch. Biochem. Biophys. 347, 174-180 (1997)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.4
NO
activation at moderate concentration, inhibition at high concentrations. Hemoglobin prevents both, activation and inhibition
Bos taurus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
NO
activation at moderate concentration, reversible inhibition at high concentrations. Hemoglobin prevents both, activation and inhibition
Bos taurus
5.3.99.5
NO
irreversible in a concentration-dependent manner
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
microsome
-
Bos taurus
-
-
5.3.99.5
microsome
-
Homo sapiens
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Bos taurus
-
-
-
5.3.99.5
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aorta
-
Bos taurus
-
5.3.99.5
platelet
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
Prostaglandin H2
i.e. PGH2
37485
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.4
NO
activation at moderate concentration, inhibition at high concentrations. Hemoglobin prevents both, activation and inhibition
Bos taurus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
NO
activation at moderate concentration, reversible inhibition at high concentrations. Hemoglobin prevents both, activation and inhibition
Bos taurus
5.3.99.5
NO
irreversible in a concentration-dependent manner
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
microsome
-
Bos taurus
-
-
5.3.99.5
microsome
-
Homo sapiens
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aorta
-
Bos taurus
-
5.3.99.5
platelet
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
Prostaglandin H2
i.e. PGH2
37485
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-