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Literature summary extracted from
- Nitric oxide modulates the activity of the hemoproteins prostaglandin I2 synthase and thromboxane A2 synthase (1997), Arch. Biochem. Biophys., 347, 174-180.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.4 | NO | activation at moderate concentration, inhibition at high concentrations. Hemoglobin prevents both, activation and inhibition | Bos taurus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.4 | NO | activation at moderate concentration, reversible inhibition at high concentrations. Hemoglobin prevents both, activation and inhibition | Bos taurus | |
| 5.3.99.5 | NO | irreversible in a concentration-dependent manner | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.3.99.4 | microsome | - |
Bos taurus | - |
- |
| 5.3.99.5 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.4 | Bos taurus | - |
- |
- |
| 5.3.99.5 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.3.99.4 | aorta | - |
Bos taurus | - |
| 5.3.99.5 | platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.5 | Prostaglandin H2 | i.e. PGH2 | Homo sapiens | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | - |
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Release 2023.1 (January 2023)
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