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Literature summary extracted from

  • Wade, M.L.; Voelkel, N.F.; Fitzpatrick, F.A.
    "Suicide" inactivation of prostaglandin I2 synthase: characterization of mechanism-based inactivation with isolated enzyme and endothelial cells (1995), Arch. Biochem. Biophys., 321, 435-458.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.4 Prostaglandin H1 slight inactivation Bos taurus
5.3.99.4 prostaglandin H2 9,11-azoprosta-5,13-dienoic acid prevents inactivation; inactivation originates primarily from a transition-state intermediate, not from malondialdehyde formed by hydrolysis of prostaglandin endoperoxides; rapid inactivation of purified enzyme during incubation with prostaglandin H2 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.4 microsome
-
 Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 aorta
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Bos taurus Prostaglandin I2 prostaglandin I2 ?