BRENDA - Enzyme Database show

Prostacyclin and thromboxane synthases

Tanabe, T.; Ullrich, V.; J. Lipid Mediat. Cell Signal. 12, 243-255 (1995)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
5.3.99.4
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Homo sapiens
formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia
?
-
-
-
5.3.99.4
Prostaglandin H2
Sus scrofa
formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Homo sapiens
-
-
-
5.3.99.4
Sus scrofa
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
5.3.99.4
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
mechanism
Homo sapiens
5.3.99.4
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
mechanism
Sus scrofa
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aorta
-
Sus scrofa
-
5.3.99.4
aorta
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
37475
Homo sapiens
Prostaglandin I2
prostaglandin I2
37475
Homo sapiens
-
5.3.99.4
Prostaglandin H2
-
37475
Sus scrofa
Prostaglandin I2
prostaglandin I2
37475
Sus scrofa
-
5.3.99.4
Prostaglandin H2
formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia
37475
Homo sapiens
?
-
-
-
-
5.3.99.4
Prostaglandin H2
formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia
37475
Sus scrofa
?
-
-
-
-
Subunits
EC Number
Subunits
Commentary
Organism
5.3.99.4
?
-
Sus scrofa
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.4
cytochrome P450
-
Homo sapiens
5.3.99.4
cytochrome P450
cytochrome-P450 enzyme
Sus scrofa
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.4
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.4
cytochrome P450
-
Homo sapiens
5.3.99.4
cytochrome P450
cytochrome-P450 enzyme
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Homo sapiens
formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia
?
-
-
-
5.3.99.4
Prostaglandin H2
Sus scrofa
formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aorta
-
Sus scrofa
-
5.3.99.4
aorta
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
37475
Homo sapiens
Prostaglandin I2
prostaglandin I2
37475
Homo sapiens
-
5.3.99.4
Prostaglandin H2
-
37475
Sus scrofa
Prostaglandin I2
prostaglandin I2
37475
Sus scrofa
-
5.3.99.4
Prostaglandin H2
formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia
37475
Homo sapiens
?
-
-
-
-
5.3.99.4
Prostaglandin H2
formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia
37475
Sus scrofa
?
-
-
-
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
5.3.99.4
?
-
Sus scrofa