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Literature summary extracted from

  • Ullrich, V.; Brugger, R.
    Prostacyclin- und Thromboxan-Synthase, neue Aspekte der Katalyse durch Hämthiolat-Enzyme (1994), Angew. Chem., 106, 1987-1996.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.4 (1R,2S)-2-phenylcyclopropanamine
-
 Bos taurus
5.3.99.4 (1R,2S)-2-phenylcyclopropanamine
-
 Sus scrofa
5.3.99.4 6-(1-Piperidyl)-2,4-diaminopyrimidine weak Bos taurus
5.3.99.4 6-(1-Piperidyl)-2,4-diaminopyrimidine weak Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.4 microsome
-
 Sus scrofa
-
-
5.3.99.4 microsome
-
 Bos taurus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.4 49200
-
 x * 49200, SDS-PAGE Sus scrofa
5.3.99.4 52000
-
 x * 52000, SDS-PAGE Bos taurus
5.3.99.4 56628
-
 x * 56628, calculation from nucleotide sequence Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Bos taurus
-
-
-
5.3.99.4 Sus scrofa
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
5.3.99.4 (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate mechanism Sus scrofa
a
5.3.99.4 (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate mechanism Bos taurus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 15-oxo-Prostaglandin H2
-
 Sus scrofa 15-oxo-Prostaglandin I2 + ?
-
 ?
5.3.99.4 15-oxo-Prostaglandin H2
-
 Bos taurus 15-oxo-Prostaglandin I2 + ?
-
 ?
5.3.99.4 8-iso-Prostaglandin H2
-
 Sus scrofa ?
-
 ?
5.3.99.4 8-iso-Prostaglandin H2
-
 Bos taurus ?
-
 ?
5.3.99.4 prostaglandin G2
-
 Sus scrofa prostaglandin I2 + 15-hydroperoxyprostacyclin
-
 ?
5.3.99.4 prostaglandin H1
-
 Bos taurus 12-hydroxyheptadecadienoic acid + malondialdehyde
-
 ?
5.3.99.4 Prostaglandin H2
-
 Sus scrofa Prostaglandin I2 prostaglandin I2 ?
5.3.99.4 Prostaglandin H2
-
 Bos taurus Prostaglandin I2 prostaglandin I2 ?
5.3.99.4 Prostaglandin H3
-
 Sus scrofa Prostaglandin I3
-
 ?
5.3.99.4 Prostaglandin H3
-
 Bos taurus Prostaglandin I3
-
 ?

Subunits

EC Number Subunits Comment Organism
5.3.99.4 ? x * 52000, SDS-PAGE Bos taurus
5.3.99.4 ? x * 49200, SDS-PAGE Sus scrofa
5.3.99.4 ? x * 56628, calculation from nucleotide sequence Bos taurus