BRENDA - Enzyme Database show

Prostacyclin- und Thromboxan-Synthase, neue Aspekte der Katalyse durch Hämthiolat-Enzyme

Ullrich, V.; Brugger, R.; Angew. Chem. 106, 1987-1996 (1994)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
(1R,2S)-2-phenylcyclopropanamine
-
Bos taurus
5.3.99.4
(1R,2S)-2-phenylcyclopropanamine
-
Sus scrofa
5.3.99.4
6-(1-Piperidyl)-2,4-diaminopyrimidine
weak
Bos taurus
5.3.99.4
6-(1-Piperidyl)-2,4-diaminopyrimidine
weak
Sus scrofa
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
microsome
-
Sus scrofa
-
-
5.3.99.4
microsome
-
Bos taurus
-
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.4
49200
-
x * 49200, SDS-PAGE
Sus scrofa
5.3.99.4
52000
-
x * 52000, SDS-PAGE
Bos taurus
5.3.99.4
56628
-
x * 56628, calculation from nucleotide sequence
Bos taurus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Bos taurus
-
-
-
5.3.99.4
Sus scrofa
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
5.3.99.4
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
mechanism
Bos taurus
5.3.99.4
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
mechanism
Sus scrofa
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
15-oxo-Prostaglandin H2
-
37474
Sus scrofa
15-oxo-Prostaglandin I2 + ?
-
37474
Sus scrofa
-
5.3.99.4
15-oxo-Prostaglandin H2
-
37474
Bos taurus
15-oxo-Prostaglandin I2 + ?
-
37474
Bos taurus
-
5.3.99.4
8-iso-Prostaglandin H2
-
37474
Sus scrofa
?
-
-
-
-
5.3.99.4
8-iso-Prostaglandin H2
-
37474
Bos taurus
?
-
-
-
-
5.3.99.4
prostaglandin G2
-
37474
Sus scrofa
prostaglandin I2 + 15-hydroperoxyprostacyclin
-
-
-
-
5.3.99.4
prostaglandin H1
-
37474
Bos taurus
12-hydroxyheptadecadienoic acid + malondialdehyde
-
-
-
-
5.3.99.4
Prostaglandin H2
-
37474
Sus scrofa
Prostaglandin I2
prostaglandin I2
37474
Sus scrofa
-
5.3.99.4
Prostaglandin H2
-
37474
Bos taurus
Prostaglandin I2
prostaglandin I2
37474
Bos taurus
-
5.3.99.4
Prostaglandin H3
-
37474
Sus scrofa
Prostaglandin I3
-
37474
Sus scrofa
-
5.3.99.4
Prostaglandin H3
-
37474
Bos taurus
Prostaglandin I3
-
37474
Bos taurus
-
Subunits
EC Number
Subunits
Commentary
Organism
5.3.99.4
?
x * 52000, SDS-PAGE; x * 56628, calculation from nucleotide sequence
Bos taurus
5.3.99.4
?
x * 49200, SDS-PAGE
Sus scrofa
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
(1R,2S)-2-phenylcyclopropanamine
-
Bos taurus
5.3.99.4
(1R,2S)-2-phenylcyclopropanamine
-
Sus scrofa
5.3.99.4
6-(1-Piperidyl)-2,4-diaminopyrimidine
weak
Bos taurus
5.3.99.4
6-(1-Piperidyl)-2,4-diaminopyrimidine
weak
Sus scrofa
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
microsome
-
Sus scrofa
-
-
5.3.99.4
microsome
-
Bos taurus
-
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.4
49200
-
x * 49200, SDS-PAGE
Sus scrofa
5.3.99.4
52000
-
x * 52000, SDS-PAGE
Bos taurus
5.3.99.4
56628
-
x * 56628, calculation from nucleotide sequence
Bos taurus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
15-oxo-Prostaglandin H2
-
37474
Sus scrofa
15-oxo-Prostaglandin I2 + ?
-
37474
Sus scrofa
-
5.3.99.4
15-oxo-Prostaglandin H2
-
37474
Bos taurus
15-oxo-Prostaglandin I2 + ?
-
37474
Bos taurus
-
5.3.99.4
8-iso-Prostaglandin H2
-
37474
Sus scrofa
?
-
-
-
-
5.3.99.4
8-iso-Prostaglandin H2
-
37474
Bos taurus
?
-
-
-
-
5.3.99.4
prostaglandin G2
-
37474
Sus scrofa
prostaglandin I2 + 15-hydroperoxyprostacyclin
-
-
-
-
5.3.99.4
prostaglandin H1
-
37474
Bos taurus
12-hydroxyheptadecadienoic acid + malondialdehyde
-
-
-
-
5.3.99.4
Prostaglandin H2
-
37474
Sus scrofa
Prostaglandin I2
prostaglandin I2
37474
Sus scrofa
-
5.3.99.4
Prostaglandin H2
-
37474
Bos taurus
Prostaglandin I2
prostaglandin I2
37474
Bos taurus
-
5.3.99.4
Prostaglandin H3
-
37474
Sus scrofa
Prostaglandin I3
-
37474
Sus scrofa
-
5.3.99.4
Prostaglandin H3
-
37474
Bos taurus
Prostaglandin I3
-
37474
Bos taurus
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
5.3.99.4
?
x * 52000, SDS-PAGE; x * 56628, calculation from nucleotide sequence
Bos taurus
5.3.99.4
?
x * 49200, SDS-PAGE
Sus scrofa