BRENDA - Enzyme Database show

Influence of human low density and high density lipoprotein cholesterol on the in vitro prostaglandin I2 synthetase activity

Beitz, J.; Forster, W.; Biochim. Biophys. Acta 620, 352-355 (1980)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.4
High density lipoprotein cholesterol
1.0 mg/ml stimulates 21%. Lower concentrations inhibit, 16% inhibition by 0.25 mg/ml
Sus scrofa
5.3.99.4
Low density lipoprotein cholesterol
0.5 mg/ml stimulates 27%. Inhibition at higher concentrations
Sus scrofa
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
Low density lipoprotein cholesterol
0.5 mg/ml stimulates 27%. Inhibition at higher concentrations. Maximal inhibition by 2 mg/ml, 64.2%
Sus scrofa
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
microsome
-
Sus scrofa
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Sus scrofa
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aorta
-
Sus scrofa
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
37462
Sus scrofa
Prostaglandin I2
prostaglandin I2
37462
Sus scrofa
-
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.4
High density lipoprotein cholesterol
1.0 mg/ml stimulates 21%. Lower concentrations inhibit, 16% inhibition by 0.25 mg/ml
Sus scrofa
5.3.99.4
Low density lipoprotein cholesterol
0.5 mg/ml stimulates 27%. Inhibition at higher concentrations
Sus scrofa
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
Low density lipoprotein cholesterol
0.5 mg/ml stimulates 27%. Inhibition at higher concentrations. Maximal inhibition by 2 mg/ml, 64.2%
Sus scrofa
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
microsome
-
Sus scrofa
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aorta
-
Sus scrofa
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
37462
Sus scrofa
Prostaglandin I2
prostaglandin I2
37462
Sus scrofa
-