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Literature summary extracted from

  • Vincent, B.; Dauch, P.; Vincent J.P.; Checler, F.
    Stably transfected human cells overexpressing rat brain endopeptidase 3.4.24.16: biochemical characterization of the activity and expression of soluble and membrane-associated counterparts (1997), J. Neurochem., 68, 837-845.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.16 overexpressed in human kidney cells, HK293 cells. The transfectants exhibit a membrane-associated form of endopeptidase-24.16, the catalytic site of which clearly faces the extracellular domain. Transfected cells are unable to secrete the enzyme Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.16 1,10-phenanthroline
-
 Rattus norvegicus
3.4.24.16 acetyl-neurotensin(8-13) inhibits degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
3.4.24.16 angiotensin I inhibits degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
3.4.24.16 angiotensin II degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
3.4.24.16 bradykinin degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
3.4.24.16 dithiothreitol
-
 Rattus norvegicus
3.4.24.16 dynorphin(1-8) degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
3.4.24.16 dynorphin(1-9) degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
3.4.24.16 EDTA
-
 Rattus norvegicus
3.4.24.16 kinetensin degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
3.4.24.16 N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-4-aminobenzoate
-
 Rattus norvegicus
3.4.24.16 Neuromedin N degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
3.4.24.16 neurotensin inhibits degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
3.4.24.16 Pro-DL-Phe-Psi(PO2CH2)-Gly-Pro-NH2
-
 Rattus norvegicus
3.4.24.16 Pro-Ile
-
 Rattus norvegicus
3.4.24.16 Substance P degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
3.4.24.16 Xenopsin degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.16 membrane the transfectants exhibit a membrane-associated form of endopeptidase-24.16, the catalytic site of which clearly faces the extracellular domain Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.16 additional information Rattus norvegicus the enzyme is likely involved in the physiological termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.16 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.16 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.16 7-methoxycoumarin-3-carboxylyl-Pro-Leu-Gly-Pro-Lys-dinitrophenyl + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.16 additional information the enzyme is likely involved in the physiological termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract Rattus norvegicus ?
-
 ?